CASIA OpenIR
IDH mutation-specific radiomic signature in lower-grade gliomas
Liu, Xing1; Li, Yiming1; Li, Shaowu2; Fan, Xing1; Sun, Zhiyan1; Yang, Zhengyi4; Wang, Kai5; Zhang, Zhong3; Jiang, Tao1,3,6,7,8,9; Liu, Yong4,10; Wang, Lei3; Wang, Yinyan3
Source PublicationAGING-US
ISSN1945-4589
2019-01-31
Volume11Issue:2Pages:673-696
Corresponding AuthorWang, Yinyan(tiantanyinyan@126.com)
AbstractUnravelling the heterogeneity is the central challenge for glioma precession oncology. In this study, we extracted quantitative image features from T2-weighted MR images and revealed that the isocitrate dehydrogenase (IDH) wild type and mutant lower grade gliomas (LGGs) differed in their expression of 146 radiomic descriptors. The logistic regression model algorithm further reduced these to 86 features. The classification model could discriminate the two types in both the training and validation sets with area under the curve values of 1.0000 and 0.9932, respectively. The transcriptome-radiomic analysis revealed that these features were associated with the immune response, biological adhesion, and several malignant behaviors, all of which are consistent with biological processes that are differentially expressed in IDH wild type and IDH mutant LGGs. Finally, a prognostic signature showed an ability to stratify IDH mutant LGGs into high and low risk groups with distinctive outcomes. By extracting a large number of radiomic features, we identified an IDH mutation-specific radiomic signature with prognostic implications. This radiomic signature may provide a way to non-invasively discriminate lower-grade gliomas as with or without the IDH mutation.
Keywordisocitrate dehydrogenase lower grade gliomas radiomic signature transcriptome-radiomic analysis prognostic signature
DOI10.18632/aging.101769
WOS KeywordANAPLASTIC GLIOMAS ; TEXTURE ANALYSIS ; CLASSIFICATION ; SURVIVAL ; FEATURES ; CANCER ; ATRX ; 2-HYDROXYGLUTARATE ; HETEROGENEITY ; METABOLISM
Indexed BySCI
Language英语
Funding ProjectBeijing Natural Science Foundation[7174295] ; National Natural Science Foundation of China[81601452] ; Beijing Postdoctoral Research Foundation[2016ZZ-37] ; National Basic Research Program of China[2015CB755500] ; National Key Research and Development Plan[2016YFC0902500]
Funding OrganizationBeijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Postdoctoral Research Foundation ; National Basic Research Program of China ; National Key Research and Development Plan
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000459384600030
PublisherIMPACT JOURNALS LLC
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25037
Collection中国科学院自动化研究所
Corresponding AuthorWang, Yinyan
Affiliation1.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
2.Capital Med Univ, Beijing Neurosurg Inst, Neurol Imaging Ctr, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Nucl Med, Beijing, Peoples R China
6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing, Peoples R China
7.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
8.Chinese Glioma Genome Atlas Network CGGA, Beijing, Peoples R China
9.Asian Glioma Genome Atlas Network AGGA, Beijing, Peoples R China
10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xing,Li, Yiming,Li, Shaowu,et al. IDH mutation-specific radiomic signature in lower-grade gliomas[J]. AGING-US,2019,11(2):673-696.
APA Liu, Xing.,Li, Yiming.,Li, Shaowu.,Fan, Xing.,Sun, Zhiyan.,...&Wang, Yinyan.(2019).IDH mutation-specific radiomic signature in lower-grade gliomas.AGING-US,11(2),673-696.
MLA Liu, Xing,et al."IDH mutation-specific radiomic signature in lower-grade gliomas".AGING-US 11.2(2019):673-696.
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