CASIA OpenIR
Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
Yang, Yongfeng1,2,3; Liu, Shu4,5; Jiang, Xiaoyan1; Yu, Hongyan2; Ding, Shuang2,3; Lu, Yanli2,3; Li, Wenqiang2,3; Zhang, Hongxing2,3; Liu, Bing4,5,6; Cui, Yue4,5,6; Fan, Lingzhong4,5,6; Jiang, Tianzi1,4,5,6,7; Lv, Luxian2,3
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
2019-02-19
Volume10Pages:10
Corresponding AuthorJiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Lv, Luxian(lvx928@126.com)
AbstractObjectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Therefore, the aim of this study was to identify the common and specific functional activity and connectivity changes in SZ, MDD, and BD. Methods: A total of 271 individuals underwent functional magnetic resonance imaging: SZ (n = 64), MDD (n= 73), BD (n = 41), and healthy controls (n = 93). The symptoms of SZ patients were evaluated by the Positive and Negative Syndrome Scale. The Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to evaluate the symptoms of MDD patients. The BDI, BAI, and Young Mania Rating Scale were used to evaluate the symptoms of MDD and BD patients. In addition, we compared the fALFF and functional connectivity between the three mental disorders and healthy controls using two sample t-tests. Results: Significantly decreased functional activity was found in the right superior frontal gyrus, middle cingulate gyrus, left middle frontal gyrus, and decreased functional connectivity (FC) of the insula was found in SZ, MDD, and BD. Specific fALFF changes, mainly in the ventral lateral pre-frontal cortex, striatum, and thalamus were found for SZ, in the left motor cortex and parietal lobe for MDD, and the dorsal lateral pre-frontal cortex, orbitofrontal cortex, and posterior cingulate cortex in BD. Conclusion: Our findings of common abnormalities in SZ, MDD, and BD provide evidence that salience network abnormality may play a critical role in the pathogenesis of these three mental disorders. Meanwhile, our findings also indicate that specific alterations in SZ, MDD, and BD provide neuroimaging evidence for the differential diagnosis of the three mental disorders.
Keywordschizophrenia major depressive disorder bipolar disorder magnetic resonance imaging functional activity
DOI10.3389/fpsyt.2019.00052
WOS KeywordLOW-FREQUENCY FLUCTUATION ; ANTERIOR CINGULATE CORTEX ; DEFAULT MODE NETWORK ; GLOBAL SIGNAL ; PREFRONTAL CORTEX ; CONNECTIVITY ; AMPLITUDE ; SCALE ; NEUROANATOMY ; RELIABILITY
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81671330] ; National Key Research and Development Program of China[2016YFC0904301] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Open Project Program of the Henan Key Lab of Biological Psychiatry[ZDSYS2015001] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; Training plan for young excellent teachers in Colleges and Universities of Henan[2016GGJS-106] ; Xinxiang Medical University
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Medical Science and Technology Research Project of Henan Province ; Open Project Program of the Henan Key Lab of Biological Psychiatry ; High Scientific and Technological Research Fund of Xinxiang Medical University ; Training plan for young excellent teachers in Colleges and Universities of Henan ; Xinxiang Medical University
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000459124800001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25043
Collection中国科学院自动化研究所
Corresponding AuthorJiang, Tianzi; Lv, Luxian
Affiliation1.Univ Elect Sci & Technol China, Key Lab Neuroinformat, Minist Educ, Sch Life Sci & Technol, Chengdu, Sichuan, Peoples R China
2.Xinxiang Med Univ, Dept Psychiat, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Peoples R China
3.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
5.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yongfeng,Liu, Shu,Jiang, Xiaoyan,et al. Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:10.
APA Yang, Yongfeng.,Liu, Shu.,Jiang, Xiaoyan.,Yu, Hongyan.,Ding, Shuang.,...&Lv, Luxian.(2019).Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder.FRONTIERS IN PSYCHIATRY,10,10.
MLA Yang, Yongfeng,et al."Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder".FRONTIERS IN PSYCHIATRY 10(2019):10.
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