CASIA OpenIR
The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia
Qin, Jiaolong1,2,3; Sui, Jing2,3,4; Ni, Huangjing5; Wang, Shuai6,7; Zhang, Fuquan6,7; Zhou, Zhenhe6,7; Tian, Lin6,7
Source PublicationFRONTIERS IN NEUROSCIENCE
ISSN1662-453X
2019-02-21
Volume13Pages:10
Corresponding AuthorTian, Lin(tianz@njmu.edu.cn)
AbstractBackground: Obsessive-compulsive disorder (OCD) and schizophrenia (SZ) as two severe mental disorders share many clinical symptoms, and have a tight association on the psychopathological level. However, the neurobiological substrates between these two diseases remain unclear. To the best of our knowledge, no study has directly compared OCD with SZ from the perspective of white matter (WM) networks. Methods: Graph theory and network-based statistic methods were applied to diffusion MRI to investigate and compare the WM topological characteristics among 29 drug-naive OCDs, 29 drug-naive SZs, and 65 demographically-matched healthy controls (NC). Results: Compared to NCs, OCDs showed the alterations of nodal efficiency and strength in orbitofrontal (OFG) and middle frontal gyrus (MFG), while SZs exhibited widely-distributed abnormalities involving the OFG, MFG, fusiform gyrus, heschl gyrus, calcarine, lingual gyrus, putamen, and thalamus, and most of these regions also showed a significant difference from OCDs. Moreover, SZs had significantly fewer connections in striatum and visual/auditory cortices than OCDs. The right putamen consistently showed significant differences between both disorders on nodal characteristics and structural connectivity. Conclusions: SZ and OCD present different level of anatomical impairment and some distinct topological patterns, and the former has more serious and more widespread disruptions. The significant differences between both disorders are observed in many regions involving the frontal, temporal, occipital, and subcortical regions. Particularly, putamen may serve as a potential imaging marker to distinguish these two disorders and may be the key difference in their pathological changes.
Keywordobsessive-compulsive disorder schizophrenia diffusion MRI graphical measures putamen network topology
DOI10.3389/fnins.2019.00096
WOS KeywordABNORMAL TOPOLOGICAL ORGANIZATION ; STRUCTURAL BRAIN NETWORKS ; AGE-OF-ONSET ; CONNECTIVITY ; MRI ; RELIABILITY ; ATTENTION ; SUBTYPES ; ANATOMY ; DORSAL
Indexed BySCI
Language英语
Funding ProjectChina Natural Science Foundation[61773380] ; China Natural Science Foundation[81871081] ; China Natural Science Foundation[81701346] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB03040100] ; Special Foundation for Jiangsu Young Medical Talents[QNRC2016175]
Funding OrganizationChina Natural Science Foundation ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Special Foundation for Jiangsu Young Medical Talents
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000459256200001
PublisherFRONTIERS MEDIA SA
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25051
Collection中国科学院自动化研究所
Corresponding AuthorTian, Lin
Affiliation1.Nanjing Univ Sci & Technol, Minist Educ, Key Lab Intelligent Percept & Syst High Dimens In, Sch Comp Sci & Engn, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China
5.Nanjing Univ Posts & Telecommun, Smart Hlth Big Data Anal & Locat Serv Engn Lab Ji, Nanjing, Jiangsu, Peoples R China
6.Nanjing Med Univ, Affiliated Wuxi Mental Hlth Ctr, Wuxi, Peoples R China
7.Wuxi Tongren Int Rehabil Hosp, Wuxi, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Qin, Jiaolong,Sui, Jing,Ni, Huangjing,et al. The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia[J]. FRONTIERS IN NEUROSCIENCE,2019,13:10.
APA Qin, Jiaolong.,Sui, Jing.,Ni, Huangjing.,Wang, Shuai.,Zhang, Fuquan.,...&Tian, Lin.(2019).The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia.FRONTIERS IN NEUROSCIENCE,13,10.
MLA Qin, Jiaolong,et al."The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia".FRONTIERS IN NEUROSCIENCE 13(2019):10.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qin, Jiaolong]'s Articles
[Sui, Jing]'s Articles
[Ni, Huangjing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qin, Jiaolong]'s Articles
[Sui, Jing]'s Articles
[Ni, Huangjing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qin, Jiaolong]'s Articles
[Sui, Jing]'s Articles
[Ni, Huangjing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.