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The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia
Qin, Jiaolong1,2,3; Sui, Jing2,3,4; Ni, Huangjing5; Wang, Shuai6,7; Zhang, Fuquan6,7; Zhou, Zhenhe6,7; Tian, Lin6,7
发表期刊FRONTIERS IN NEUROSCIENCE
ISSN1662-453X
2019-02-21
卷号13页码:10
通讯作者Tian, Lin(tianz@njmu.edu.cn)
摘要Background: Obsessive-compulsive disorder (OCD) and schizophrenia (SZ) as two severe mental disorders share many clinical symptoms, and have a tight association on the psychopathological level. However, the neurobiological substrates between these two diseases remain unclear. To the best of our knowledge, no study has directly compared OCD with SZ from the perspective of white matter (WM) networks. Methods: Graph theory and network-based statistic methods were applied to diffusion MRI to investigate and compare the WM topological characteristics among 29 drug-naive OCDs, 29 drug-naive SZs, and 65 demographically-matched healthy controls (NC). Results: Compared to NCs, OCDs showed the alterations of nodal efficiency and strength in orbitofrontal (OFG) and middle frontal gyrus (MFG), while SZs exhibited widely-distributed abnormalities involving the OFG, MFG, fusiform gyrus, heschl gyrus, calcarine, lingual gyrus, putamen, and thalamus, and most of these regions also showed a significant difference from OCDs. Moreover, SZs had significantly fewer connections in striatum and visual/auditory cortices than OCDs. The right putamen consistently showed significant differences between both disorders on nodal characteristics and structural connectivity. Conclusions: SZ and OCD present different level of anatomical impairment and some distinct topological patterns, and the former has more serious and more widespread disruptions. The significant differences between both disorders are observed in many regions involving the frontal, temporal, occipital, and subcortical regions. Particularly, putamen may serve as a potential imaging marker to distinguish these two disorders and may be the key difference in their pathological changes.
关键词obsessive-compulsive disorder schizophrenia diffusion MRI graphical measures putamen network topology
DOI10.3389/fnins.2019.00096
关键词[WOS]ABNORMAL TOPOLOGICAL ORGANIZATION ; STRUCTURAL BRAIN NETWORKS ; AGE-OF-ONSET ; CONNECTIVITY ; MRI ; RELIABILITY ; ATTENTION ; SUBTYPES ; ANATOMY ; DORSAL
收录类别SCI
语种英语
资助项目China Natural Science Foundation[61773380] ; China Natural Science Foundation[81871081] ; China Natural Science Foundation[81701346] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB03040100] ; Special Foundation for Jiangsu Young Medical Talents[QNRC2016175] ; China Natural Science Foundation[61773380] ; China Natural Science Foundation[81871081] ; China Natural Science Foundation[81701346] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB03040100] ; Special Foundation for Jiangsu Young Medical Talents[QNRC2016175]
项目资助者China Natural Science Foundation ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Special Foundation for Jiangsu Young Medical Talents
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000459256200001
出版者FRONTIERS MEDIA SA
七大方向——子方向分类脑网络分析
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/25051
专题脑网络组研究
通讯作者Tian, Lin
作者单位1.Nanjing Univ Sci & Technol, Minist Educ, Key Lab Intelligent Percept & Syst High Dimens In, Sch Comp Sci & Engn, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China
5.Nanjing Univ Posts & Telecommun, Smart Hlth Big Data Anal & Locat Serv Engn Lab Ji, Nanjing, Jiangsu, Peoples R China
6.Nanjing Med Univ, Affiliated Wuxi Mental Hlth Ctr, Wuxi, Peoples R China
7.Wuxi Tongren Int Rehabil Hosp, Wuxi, Peoples R China
第一作者单位模式识别国家重点实验室
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Qin, Jiaolong,Sui, Jing,Ni, Huangjing,et al. The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia[J]. FRONTIERS IN NEUROSCIENCE,2019,13:10.
APA Qin, Jiaolong.,Sui, Jing.,Ni, Huangjing.,Wang, Shuai.,Zhang, Fuquan.,...&Tian, Lin.(2019).The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia.FRONTIERS IN NEUROSCIENCE,13,10.
MLA Qin, Jiaolong,et al."The Shared and Distinct White Matter Networks Between Drug-Naive Patients With Obsessive-Compulsive Disorder and Schizophrenia".FRONTIERS IN NEUROSCIENCE 13(2019):10.
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