CASIA OpenIR  > 中国科学院分子影像重点实验室
Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer
Yan, Hao1,2; Shang, Wenting3; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Xiumei1; Zhang, Shuixing4; Xu, Nan1; Xu, Wanhai5; Tian, Jie3; Kang, Feiyu1,2
发表期刊NANOSCALE
ISSN2040-3364
2019-01-14
卷号11期号:2页码:706-716
通讯作者Xu, Wanhai(xuwanhai@163.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Kang, Feiyu(fykang@mail.tsinghua.edu.cn)
摘要Nano-photothermal therapy (NPTT) has attracted increasing interest recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems have been synthesized and applied for preoperative NPTT to assist in the follow-up surgery, termed "neoadjuvant NPTT". Remarkably, nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between the tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery groups. Therefore, NPTT can effectively assist in surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in the future.
DOI10.1039/c8nr08109c
关键词[WOS]NANOPARTICLES ; CHEMOTHERAPY ; NANOSHELLS
收录类别SCI
语种英语
资助项目National Key Research and Development Program of China[2016YFB0700800] ; Intergovernmental Cooperation in Science and Technology[2016YFE0125300] ; NSFC[81172182] ; NSFC[81671829] ; fund of Key Laboratory of Advanced Materials of Ministry of Education[2017AML12] ; National Key Research and Development Program of China[2016YFB0700800] ; Intergovernmental Cooperation in Science and Technology[2016YFE0125300] ; NSFC[81172182] ; NSFC[81671829] ; fund of Key Laboratory of Advanced Materials of Ministry of Education[2017AML12]
项目资助者National Key Research and Development Program of China ; Intergovernmental Cooperation in Science and Technology ; NSFC ; fund of Key Laboratory of Advanced Materials of Ministry of Education
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000455001600035
出版者ROYAL SOC CHEMISTRY
七大方向——子方向分类医学影像处理与分析
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/25640
专题中国科学院分子影像重点实验室
通讯作者Xu, Wanhai; Tian, Jie; Kang, Feiyu
作者单位1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
2.Tsinghua Univ, Grad Sch Shenzhen, Engn Lab Functionalized Carbon Mat, Shenzhen 518055, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Jinan Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou, Guangdong, Peoples R China
5.Harbin Med Univ, Hosp 4, Urol Surg Dept, Harbin 150001, Heilongjiang, Peoples R China
通讯作者单位中国科学院自动化研究所
推荐引用方式
GB/T 7714
Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer[J]. NANOSCALE,2019,11(2):706-716.
APA Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Xiumei.,...&Kang, Feiyu.(2019).Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer.NANOSCALE,11(2),706-716.
MLA Yan, Hao,et al."Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer".NANOSCALE 11.2(2019):706-716.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yan, Hao]的文章
[Shang, Wenting]的文章
[Sun, Xiaodan]的文章
百度学术
百度学术中相似的文章
[Yan, Hao]的文章
[Shang, Wenting]的文章
[Sun, Xiaodan]的文章
必应学术
必应学术中相似的文章
[Yan, Hao]的文章
[Shang, Wenting]的文章
[Sun, Xiaodan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。