CASIA OpenIR
Functional Connectivity of Anterior Insula Predicts Recovery of Patients With Disorders of Consciousness
Zhang, Li1; Luo, Lunjie2; Zhou, Zhen3; Xu, Kaibin4; Zhang, Lijuan5; Liu, Xiaoyan6,7; Tan, Xufei6,7; Zhang, Jie1; Ye, Xiangming1; Gao, Jian5; Luo, Benyan6,7
Source PublicationFRONTIERS IN NEUROLOGY
ISSN1664-2295
2018-11-30
Volume9Pages:10
Corresponding AuthorGao, Jian(vanjeff@163.com) ; Luo, Benyan(luobenyan@zju.edu.cn)
AbstractBackground: We hypothesize that the anterior insula is important for maintenance of awareness. Here, we explored the functional connectivity alterations of the anterior insula with changes in the consciousness level or over time in patients with disorders of consciousness (DOC) and determined potential correlation with clinical outcomes. Methods: We examined 20 participants (9 patients with DOC and 11 healthy controls). Each patient underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized Coma Recovery Scale-Revised (CRS-R) assessment on the same day. We categorized the patients according to the prognosis: those who emerged from a minimally conscious state (recovery group, n = 4) and those who remained in the unconscious state (unrecovery group, n = 5). Two rs-fMRI scans were obtained from all patients, and the second scan of patients in the recovery group was obtained after they regained consciousness. We performed seed-based fMRI analysis and selected the left ventral agranular insula (vAI) and dorsal agranular insula (dAI) as the regions of interest. Correlations with CRS-R were determined with the Spearman's correlation coefficient. Results: Compared with healthy controls, the functional connectivity between dAI and gyrus rectus of patients who recovered was significantly increased (p < 0.001, cluster-wise family-wise error rate [EWER] < 0.05). The second rs-fMRI scan of patients who remained with DOC showed a significant decreased functional connectivity between the dAI to contralateral insula, pallidum, bilateral inferior parietal lobule (IPL), precentral gyrus, and middle cingulate cortex (p < 0.001, cluster-wise FWER < 0.05) as well as the functional connectivity between vAI to caudate and cingulum contrast to controls (p < 0.001, cluster-wise FWER < 0.05). Finally, the functional connectivity strength of dAI-temporal pole (Spearman r = 0.491, p < 0.05) and dAI-IPL (Spearman r = 0.579, p < 0.05) were positively correlated with CRS-R scores in all DOC patients. The connectivity of dAl-IPL was also positively correlated with clinical scores in the recovery group (Spearman r = 0.807, p < 0.05). Conclusions: Our findings indicate that the recovery of consciousness is associated with an increased connectivity of the dAI to IPL and temporal pole. This possibly highlights the role of the insula in human consciousness. Moreover, longitudinal variations in dAI-IPL and dAI-temporal pole connectivity may be potential hallmarks in the outcome prediction of DOC patients.
Keywordinsula disorders of consciousness resting-state functional magnetic resonance imaging functional connectivity inferior parietal lobule
DOI10.3389/fneur.2018.01024
WOS KeywordDEFAULT MODE ; NETWORK ; STATE ; LEVEL ; LOBE ; MRI
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000451949700002
PublisherFRONTIERS MEDIA SA
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25694
Collection中国科学院自动化研究所
Corresponding AuthorGao, Jian; Luo, Benyan
Affiliation1.Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China
3.Zhejiang Univ, Coll Comp Sci & Technol, Hangzhou, Zhejiang, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
5.Hangzhou Hosp Zhejiang CAPR, Dept Rehabil, Hangzhou, Zhejiang, Peoples R China
6.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Neurol, Hangzhou, Zhejiang, Peoples R China
7.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Brain Med Ctr, Hangzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Li,Luo, Lunjie,Zhou, Zhen,et al. Functional Connectivity of Anterior Insula Predicts Recovery of Patients With Disorders of Consciousness[J]. FRONTIERS IN NEUROLOGY,2018,9:10.
APA Zhang, Li.,Luo, Lunjie.,Zhou, Zhen.,Xu, Kaibin.,Zhang, Lijuan.,...&Luo, Benyan.(2018).Functional Connectivity of Anterior Insula Predicts Recovery of Patients With Disorders of Consciousness.FRONTIERS IN NEUROLOGY,9,10.
MLA Zhang, Li,et al."Functional Connectivity of Anterior Insula Predicts Recovery of Patients With Disorders of Consciousness".FRONTIERS IN NEUROLOGY 9(2018):10.
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