Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis

doi:10.3389/fphar.2018.01393

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	Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis
	Zhuo, Chuanjun 1,2,3,4,5,6; Xu, Yong 4,5,6; Liu, Sha 4,5,6; Li, Jing 4,5,6; Zheng, Qishi 7; Gao, Xiangyang 8; Li, Shen 3; Jing, Rixing9 ; Song, Xueqin 10; Yue, Weihua 11,12,13; Zhou, Chunhua 14; Upthegrove, Rachel 15,16
发表期刊	FRONTIERS IN PHARMACOLOGY
ISSN	1663-9812
	2018-11-28
卷号	9 页码:10
通讯作者	Zhuo, Chuanjun(chuanjunzhuotjmh@163.com) ; Yue, Weihua(dryue@bjmu.edu.cn) ; Zhou, Chunhua(zhouchunhua80@126.com)
摘要	Background: Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. Methods: A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Network meta-analyses, comparing the body weight change, BMI change and withdrawn due to adverse events of different pharmacological add-ons, was performed using a multivariate meta-regression model with random-effects, adopting a frequentist approach. To rank the prognosis for all add-ons, we used surface under the cumulative ranking (SUCRA) values. Outcomes: From 614 potential studies identified, 27 eligible studies (n = 1,349 subjects) were included. All the studies demonstrated low to moderate risk of bias. For the analysis of body weight change, all add-ons except Ranitidine showed significant weight reductions comparing to placebo. The effectiveness rank based on SUCRA results from highest to lowest was Sibutramine, Topiramate, Metformin, Reboxetine, Ranitidine, and placebo. A similar pattern was seen for BMI change. The analysis of safety outcome did not detect significantly increased withdrawn number from the add-ons. Current evidence showed relatively good tolerance and safety of using the pharmacological add-ons. Interpretation: Topiramate and Metformin are effective add-on treatments in controlling antipsychotic-induced weight gain, comparing to placebo. They are well tolerated in short-term period. Although Sibutramine has the highest rank of the effectiveness, its license has been withdrawn in many countries due to its adverse effects. Hence, Sibutramine should not be adopted to treat antipsychotic-induced weight gain.
关键词	antipsychotic-induced weight gain network meta-analysis pharmacological add-ons topiramate metformin
DOI	10.3389/fphar.2018.01393
关键词[WOS]	PLACEBO-CONTROLLED TRIAL ; OLANZAPINE-TREATED PATIENTS ; AUTISM SPECTRUM DISORDER ; DOUBLE-BLIND ; BODY-WEIGHT ; METABOLIC DYSFUNCTION ; OPEN-LABEL ; 1ST-EPISODE SCHIZOPHRENIA ; OBESE-PATIENTS ; YOUNG-PEOPLE
收录类别	SCI
语种	英语
资助项目	Tianjin Health Bureau Foundation[2014KR02] ; National Natural Science Foundation of China[81871052] ; National Natural Science Foundation of China[81701326] ; National Natural Science Foundation of China[81571319] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; National Key Research and Development Program of China[2016YFC1307004] ; Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team[201705D131027] ; Tianjin Health Bureau Foundation[2014KR02] ; National Natural Science Foundation of China[81871052] ; National Natural Science Foundation of China[81701326] ; National Natural Science Foundation of China[81571319] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; National Key Research and Development Program of China[2016YFC1307004] ; Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team[201705D131027]
项目资助者	Tianjin Health Bureau Foundation ; National Natural Science Foundation of China ; Key Projects of the Natural Science Foundation of Tianjin, China ; National Key Research and Development Program of China ; Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000451647300001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/25702
专题	模式识别国家重点实验室
通讯作者	Zhuo, Chuanjun; Yue, Weihua; Zhou, Chunhua
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Dept Psychiat & Morbid, Tianjin, Peoples R China 2.Jining Med Univ, Dept Psychiat, Jining, Peoples R China 3.Tianjin Med Univ, Dept Psychiat, Tianjin, Peoples R China 4.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 5.Shanxi Med Univ, Hosp 1, MDT Ctr Cognit Impairment & Sleep Disorders, Taiyuan, Shanxi, Peoples R China 6.Shanxi Med Univ, Minist Educ, Key Lab Cellular Physiol, Dept Neurobiol,Natl Key Disciplines, Taiyuan, Shanxi, Peoples R China 7.Singapore Clin Res Inst, Dept Epidemiol, Singapore, Singapore 8.Chinese Peoples Liberat Army Gen Hosp, Big Data Anal Ctr, Hlth Management Inst, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Automat, China Natl Key Lab, Dept Pattern Recognit, Beijing, Peoples R China 10.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Henan, Peoples R China 11.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China 12.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 13.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 14.Hebei Med Univ, Hosp 1, Dept Pharm, Shijiazhuang, Hebei, Peoples R China 15.Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England 16.Forward Thinking Birmingham, Early Intervent Serv, Birmingham, W Midlands, England
推荐引用方式 GB/T 7714	Zhuo, Chuanjun,Xu, Yong,Liu, Sha,et al. Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis[J]. FRONTIERS IN PHARMACOLOGY,2018,9:10.
APA	Zhuo, Chuanjun.,Xu, Yong.,Liu, Sha.,Li, Jing.,Zheng, Qishi.,...&Upthegrove, Rachel.(2018).Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.FRONTIERS IN PHARMACOLOGY,9,10.
MLA	Zhuo, Chuanjun,et al."Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis".FRONTIERS IN PHARMACOLOGY 9(2018):10.