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Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy
Su, Yanhong1,2,3; Wang, Kun3,4; Li, Yong2; Song, Wenjing5; Xin, Yongjie2; Zhao, Wei2; Tian, Jie3,4; Ren, Li1,5; Lu, Ligong1,2
Source PublicationNANOMEDICINE
ISSN1743-5889
2018-05-01
Volume13Issue:9Pages:1009-1023
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Ren, Li(psliren@scut.edu.cn) ; Lu, Ligong(luligong1969@126.com)
AbstractAim: The clinical application of sorafenib is limited because of its hydrophobicity, low bioavailability and unsatisfying treatment effect. Therefore, sorafenib-loaded PEG-poly (e-caprolactone) micelles (SF micelles) were fabricated for sorafenib delivery. Materials & methods: In vitro assays investigated the solubility, dispersity, stability, cytotoxicity and uptake capacity of SF micelles. In vivo biodistribution and therapeutic effects were studied using HepG2-Luc tumor-bearing mice. Results: SF micelles had a regular spherical structure with good water solubility. In vivo imaging results showed PEG-poly (e-caprolactone) micelles could elevate the sorafenib concentration in tumor tissues. Meanwhile, SF micelles exhibited higher tumor growth inhibition in vivo. Conclusion: SF micelles might be a potential drug delivery system, which could enhance the therapeutic effects of sorafenib.
Keyworddrug delivery hepatocellular carcinoma micelles sorafenib therapy
DOI10.2217/nnm-2018-0046
WOS KeywordCANCER-THERAPY ; DRUG-DELIVERY ; CO-DELIVERY ; IN-VIVO ; NANOPARTICLES ; SYSTEM ; CELLS ; DOXORUBICIN ; LIPOSOMES ; NANOPLATFORM
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0103702] ; National Key Research and Development Program of China[2016YFA0201401] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[21604025] ; National Natural Science Foundation of China[51273072] ; National Natural Science Foundation of China[81701771] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2014B090907004] ; Natural Science Foundation of Guangdong Province, China[2016A030310461] ; Science and Technology Foundation of Guangdong Province, China[2013B021800180] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0103702] ; National Key Research and Development Program of China[2016YFA0201401] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[21604025] ; National Natural Science Foundation of China[51273072] ; National Natural Science Foundation of China[81701771] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2014B090907004] ; Natural Science Foundation of Guangdong Province, China[2016A030310461] ; Science and Technology Foundation of Guangdong Province, China[2013B021800180]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Science and Technology Foundation of Guangdong Province, China
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000435412500005
PublisherFUTURE MEDICINE LTD
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25832
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie; Ren, Li; Lu, Ligong
Affiliation1.South China Univ Technol, Sch Med, Guangzhou 510006, Guangdong, Peoples R China
2.Zhuhai Peoples Hosp, Ctr Intervent Radiol, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China
5.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Su, Yanhong,Wang, Kun,Li, Yong,et al. Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy[J]. NANOMEDICINE,2018,13(9):1009-1023.
APA Su, Yanhong.,Wang, Kun.,Li, Yong.,Song, Wenjing.,Xin, Yongjie.,...&Lu, Ligong.(2018).Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy.NANOMEDICINE,13(9),1009-1023.
MLA Su, Yanhong,et al."Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy".NANOMEDICINE 13.9(2018):1009-1023.
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