CASIA OpenIR  > 中国科学院分子影像重点实验室
Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle
Hu, Min1,2,3,4; Wang, Kun2,4; Shang, Wenting2,4; Han, Ziyu1,5; Jiang, Hongmei2; Fang, Chihua1,5; Tian, Jie2,4
Source PublicationPARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
ISSN0934-0866
2019-08-01
Volume36Issue:8Pages:12
Corresponding AuthorFang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractHepatectomy is one of the main treatments for hepatocellular carcinoma (HCC). However, because microscopic tumor residues are often present after surgery, the recurrence rate of HCC remains extremely high. A multimodality imaging-guided multifunctional nanoparticle, indocyanine-green-gadolinium-copper sulfide@bovine-serum-albumin-epithelial-cell-adhesion molecule (EpCAM), is developed for HCC treatment based on a novel theranostic strategy. After intravenous injection of these nanoparticles into HCC-bearing mice, remarkably selective accumulation and highly efficient retention of the nanoparticles in tumor sites are observed. This is due to the EpCAM's specific targeting ability, which also results in enhanced HCC contrast in a tri-modal visualization, which unites magnetic resonance, photoacoustic, and fluorescence imaging. Moreover, nanoparticle uptake into the HCC allows photothermal therapy (PTT) as an interoperative adjuvant strategy for further eliminating possible microscopic residues and boosting HCC surgery outcomes. This theranostic strategy not only helps with precise diagnosis of HCC but enables intraoperatively imaging guidance for accurate tumor resection. Moreover, postoperation longitudinal observation demonstrates that intraoperative imaging-guided resection alongside a PTT-integrated treatment strategy can result in a significant improvement of overall survival rate. These multifunctional EpCAM-targeting nanoparticles may respresent a novel theranostic strategy to improve postsurgical HCC treatment.
Keywordfluorescence-guided surgery hepatocellular carcinoma intraoperative photothermal therapy triple-modality imaging
DOI10.1002/ppsc.201900085
WOS KeywordPHOTOTHERMAL THERAPY ; CANCER STATISTICS ; REAL-TIME ; ALBUMIN ; RECURRENCE ; CELLS ; IDENTIFICATION ; TOMOGRAPHY ; RESECTION
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000482449300007
PublisherWILEY-V C H VERLAG GMBH
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25833
Collection中国科学院分子影像重点实验室
Corresponding AuthorFang, Chihua; Tian, Jie
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Jinan Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510630, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Inst Automat, Beijing 100080, Peoples R China
5.Res Ctr Digital Med, Guangdong Prov Clin & Engn Technol, Guangzhou 510280, Guangdong, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Min,Wang, Kun,Shang, Wenting,et al. Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2019,36(8):12.
APA Hu, Min.,Wang, Kun.,Shang, Wenting.,Han, Ziyu.,Jiang, Hongmei.,...&Tian, Jie.(2019).Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,36(8),12.
MLA Hu, Min,et al."Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 36.8(2019):12.
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