Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle

doi:10.1002/ppsc.201900085

	Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle
	Hu, Min 1,2,3,4; Wang, Kun2,4 ; Shang, Wenting2,4 ; Han, Ziyu 1,5; Jiang, Hongmei 2; Fang, Chihua 1,5; Tian, Jie 2,4
发表期刊	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
ISSN	0934-0866
	2019-08-01
卷号	36 期号:8 页码:12
通讯作者	Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Hepatectomy is one of the main treatments for hepatocellular carcinoma (HCC). However, because microscopic tumor residues are often present after surgery, the recurrence rate of HCC remains extremely high. A multimodality imaging-guided multifunctional nanoparticle, indocyanine-green-gadolinium-copper sulfide@bovine-serum-albumin-epithelial-cell-adhesion molecule (EpCAM), is developed for HCC treatment based on a novel theranostic strategy. After intravenous injection of these nanoparticles into HCC-bearing mice, remarkably selective accumulation and highly efficient retention of the nanoparticles in tumor sites are observed. This is due to the EpCAM's specific targeting ability, which also results in enhanced HCC contrast in a tri-modal visualization, which unites magnetic resonance, photoacoustic, and fluorescence imaging. Moreover, nanoparticle uptake into the HCC allows photothermal therapy (PTT) as an interoperative adjuvant strategy for further eliminating possible microscopic residues and boosting HCC surgery outcomes. This theranostic strategy not only helps with precise diagnosis of HCC but enables intraoperatively imaging guidance for accurate tumor resection. Moreover, postoperation longitudinal observation demonstrates that intraoperative imaging-guided resection alongside a PTT-integrated treatment strategy can result in a significant improvement of overall survival rate. These multifunctional EpCAM-targeting nanoparticles may respresent a novel theranostic strategy to improve postsurgical HCC treatment.
关键词	fluorescence-guided surgery hepatocellular carcinoma intraoperative photothermal therapy triple-modality imaging
DOI	10.1002/ppsc.201900085
关键词[WOS]	PHOTOTHERMAL THERAPY ; CANCER STATISTICS ; REAL-TIME ; ALBUMIN ; RECURRENCE ; CELLS ; IDENTIFICATION ; TOMOGRAPHY ; RESECTION
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000482449300007
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/25833
专题	中国科学院分子影像重点实验室
通讯作者	Fang, Chihua; Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou 510630, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Inst Automat, Beijing 100080, Peoples R China 5.Res Ctr Digital Med, Guangdong Prov Clin & Engn Technol, Guangzhou 510280, Guangdong, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Hu, Min,Wang, Kun,Shang, Wenting,et al. Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2019,36(8):12.
APA	Hu, Min.,Wang, Kun.,Shang, Wenting.,Han, Ziyu.,Jiang, Hongmei.,...&Tian, Jie.(2019).Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,36(8),12.
MLA	Hu, Min,et al."Boosting Postsurgical Outcomes of Orthotopic Hepatocellular Carcinoma via an EpCAM-Targeting Theranostic Nanoparticle".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 36.8(2019):12.

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