CASIA OpenIR  > 中国科学院分子影像重点实验室
Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy
Du, Yang1,2; Liu, Xiaoli2,3; Liang, Qian1,2; Liang, Xing-Jie2,3; Tian, Jie1,2,4,5
Source PublicationNANO LETTERS
ISSN1530-6984
2019-06-01
Volume19Issue:6Pages:3618-3626
Corresponding AuthorLiang, Xing-Jie(liangxj@nanoctr.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractTwo major technical challenges of magnetic hyperthermia are quantitative assessment of agent distribution during and following administration and achieving uniform heating of the tumor at the desired temperature without damaging the surrounding tissues. In this study, we developed a multimodal MRI/MPI theranostic agent with active biological targeting for improved magnetic hyperthermia therapy (MHT). First, by systematically elucidating the magnetic nanoparticle magnetic characteristics and the magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) signal enhancement effects, which are based on the magnetic anisotropy, size, and type of nanoparticles, we found that 18 nm iron oxide NPs (IOs) could be used as superior nanocrystallines for high performance of MRI/MPI contrast agents in vitro. To improve the delivery uniformity, we then targeted tumors with the 18 nm IOs using a tumor targeting peptide, CREKA. Both MRI and MPI signals showed that the targeting agent improves the intratumoral delivery uniformity of nanoparticles in a 4T1 orthotopic mouse breast cancer model. Lastly, the in vivo antitumor MHT effect was evaluated, and the data showed that the improved targeting and delivery uniformity enables more effective magnetic hyperthermia cancer ablation than otherwise identical, nontargeting IOs. This preclinical study of image-guided MHT using cancer-targeting IOs and a novel MPI system paves the way for new MHT strategies.
KeywordMagnetic hyperthermia therapy (MHT) magnetic resonance imaging (MRI) magnetic particle imaging (MPI) magnetic ferrite nanoparticles (MFNPs) theranostics
DOI10.1021/acs.nanolett.9b00630
WOS KeywordIRON-OXIDE NANOPARTICLES ; MRI ; NANOMATERIALS ; ENHANCEMENT ; NANORINGS ; PLATFORM ; AGENT ; MPI ; T-1
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2017YFA0700401] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; NSFC-DFG project[31761133013] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Natural Science Foundation[31630027] ; Natural Science Foundation[31430031]
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; NSFC-DFG project ; Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Natural Science Foundation
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000471834900029
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26003
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiang, Xing-Jie; Tian, Jie
Affiliation1.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11,First North Rd, Beijing 100190, Peoples R China
4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100190, Peoples R China
5.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Du, Yang,Liu, Xiaoli,Liang, Qian,et al. Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy[J]. NANO LETTERS,2019,19(6):3618-3626.
APA Du, Yang,Liu, Xiaoli,Liang, Qian,Liang, Xing-Jie,&Tian, Jie.(2019).Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy.NANO LETTERS,19(6),3618-3626.
MLA Du, Yang,et al."Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy".NANO LETTERS 19.6(2019):3618-3626.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Du, Yang]'s Articles
[Liu, Xiaoli]'s Articles
[Liang, Qian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Du, Yang]'s Articles
[Liu, Xiaoli]'s Articles
[Liang, Qian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Du, Yang]'s Articles
[Liu, Xiaoli]'s Articles
[Liang, Qian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.