Cognitive Decline Before and After Incident Coronary Events

doi:10.1016/j.jacc.2019.04.019

	Cognitive Decline Before and After Incident Coronary Events
	Xie, Wuxiang 1,2; Zheng, Fanfan3,4 ; Yan, Li 2; Zhong, Baoliang 5
发表期刊	JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
ISSN	0735-1097
	2019-06-25
卷号	73 期号:24 页码:3041-3050
通讯作者	Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn)
摘要	BACKGROUND Previous studies have suggested that coronary heart disease (CHD) may be associated with accelerated cognitive decline. However, the temporal pattern of cognitive decline before and after incident CHD remains largely unknown. OBJECTIVES The purpose of this study was to determine the cognitive trajectory before and after incident CHD diagnosis in a national representative cohort age >= 50 years. METHODS This study included 7,888 participants (mean age 62.1 +/- 10.2 years) with no history of stroke or incident stroke during follow-up from the English Longitudinal Study of Ageing. Participants underwent a cognitive assessment at baseline (wave 1, 2002 to 2003), and at least 1 other time point (from wave 2 [2004 to 2005] to wave 8 [2016 to 2017]). Incident CHD was identified as a diagnosis of myocardial infarction and/or angina during follow-up. RESULTS Incident CHD was associated with accelerated cognitive decline during a median follow-up of 12 years. The annual rate of cognitive decline before CHD diagnosis among individuals who experienced incident CHD was similar to that of participants who remained CHD-free throughout follow-up. No short-term cognitive decline was observed in participants with CHD diagnosis after the event. In the years following CHD diagnosis, global cognition, verbal memory, and temporal orientation scores declined significantly faster than they did before the event, after multivariable adjustment. Sensitivity analyses yielded similar results. CONCLUSIONS Incident CHD is associated with accelerated cognitive decline after, but not before, the event. Attention should be drawn to the long-term cognitive deterioration related to CHD. Careful monitoring of cognitive function is warranted in CHD patients in the years following the event. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
关键词	cognitive decline coronary heart disease English Longitudinal Study of Ageing linear mixed model
DOI	10.1016/j.jacc.2019.04.019
关键词[WOS]	VASCULAR-DISEASE ; RISK-FACTORS ; IMPAIRMENT ; DEMENTIA ; STROKE ; POPULATION ; LIFE ; AGE
收录类别	SCI
语种	英语
资助项目	Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804] ; Beijing Natural Science Foundation[7182108] ; National Natural Science Foundation of China[81601176] ; National Natural Science Foundation of China[81601176] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804]
项目资助者	National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences
WOS研究方向	Cardiovascular System & Cardiology
WOS类目	Cardiac & Cardiovascular Systems
WOS记录号	WOS:000471773400002
出版者	ELSEVIER SCIENCE INC
引用统计	被引频次：122[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/26074
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Xie, Wuxiang
作者单位	1.Peking Univ, Hlth Sci Ctr, Clin Res Inst, 38 Xueyuan Rd, Beijing 100191, Peoples R China 2.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus,Norfolk Pl, London W2 1PG, England 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.UCL, Inst Cognit Neurosci, London, England 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Dept Geriatr Psychiat, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Xie, Wuxiang,Zheng, Fanfan,Yan, Li,et al. Cognitive Decline Before and After Incident Coronary Events[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2019,73(24):3041-3050.
APA	Xie, Wuxiang,Zheng, Fanfan,Yan, Li,&Zhong, Baoliang.(2019).Cognitive Decline Before and After Incident Coronary Events.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,73(24),3041-3050.
MLA	Xie, Wuxiang,et al."Cognitive Decline Before and After Incident Coronary Events".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 73.24(2019):3041-3050.