CASIA OpenIR
Altered Resting-State Functional Activity in Patients With Autism Spectrum Disorder: A Quantitative Meta-Analysis
Wang, Wenhui1,2; Liu, Jia3; Shi, Shaojie1,2; Liu, Taiyuan1,2; Ma, Lun1,2; Ma, Xiaoyue1,2; Tian, Jie4,5; Gong, Qiyong6; Wang, Meiyun1,2
Source PublicationFRONTIERS IN NEUROLOGY
ISSN1664-2295
2018-07-24
Volume9Pages:9
Corresponding AuthorWang, Meiyun(mywang@ha.edu.cn)
AbstractBackground: There is accumulating evidence showing that patients with autism spectrum disorder (ASD) have obvious changes in resting-state functional brain activity. So far, there have been no meta-analyses of the resting-state brain activity alterations in patients with ASD. We attempted to explore the resting-state functional activity changes in patients with ASD, possibly providing a new perspective for investigating the pathophysiology of patients with ASD. Methods: We screened relevant studies published before August 2017 in PubMed, Ovid, Web of Science, China National Knowledge Infrastructure (CNKI), and the Wan-fang database. Fifteen resting-state functional neural activity datasets (including 382 patients and 348 healthy controls) were included. Through the use of the effect-size signed differential mapping (ES-SDM) method, we carried out a meta-analysis of resting-state functional activity studies of patients with ASD. Results: Compared with healthy controls, patients with ASD showed hyperactivity in the right supplementary motor area, middle frontal gyrus, inferior frontal gyrus, the left precentral gyrus, and the bilateral cerebellum hemispheric lobule (VIII/IX), and hypoactivity in the right middle temporal gyrus, superior temporal gyrus, and the left precuneus, posterior cingulate cortex, median cingulate cortex, and bilateral cerebellum (crus I). Conclusion: This meta-analysis indicates that patients with ASD have significant and robust resting-state brain activity alterations in the language comprehension network, inferior-posterior cerebellum, default mode network (DMN), and cerebellar crus I. These brain regions may serve as specific regions of interest for further studies of ASD, which will allow us to further clarify the neurobiological mechanisms in patients with ASD.
Keywordautism spectrum disorder meta-analysis regional homogeneity functional neuroimaging resting state
DOI10.3389/fneur.2018.00556
WOS KeywordVOXEL-BASED MORPHOMETRY ; BRAINS DEFAULT NETWORK ; GRAY-MATTER ; LANGUAGE COMPREHENSION ; CONNECTIVITY ; CEREBELLUM ; ANATOMY ; ADULTS ; MRI ; CHILDREN
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation[31470047] ; National Natural Science Foundation[81271565] ; Henan Province Scientific and Technological Innovation Talents Project ; National Natural Science Foundation[31470047] ; National Natural Science Foundation[81271565] ; Henan Province Scientific and Technological Innovation Talents Project
Funding OrganizationNational Natural Science Foundation ; Henan Province Scientific and Technological Innovation Talents Project
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000439598000001
PublisherFRONTIERS MEDIA SA
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26318
Collection中国科学院自动化研究所
Corresponding AuthorWang, Meiyun
Affiliation1.Zhengzhou Univ, Dept Radiol, Peoples Hosp, Zhengzhou, Henan, Peoples R China
2.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China
4.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
6.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Wenhui,Liu, Jia,Shi, Shaojie,et al. Altered Resting-State Functional Activity in Patients With Autism Spectrum Disorder: A Quantitative Meta-Analysis[J]. FRONTIERS IN NEUROLOGY,2018,9:9.
APA Wang, Wenhui.,Liu, Jia.,Shi, Shaojie.,Liu, Taiyuan.,Ma, Lun.,...&Wang, Meiyun.(2018).Altered Resting-State Functional Activity in Patients With Autism Spectrum Disorder: A Quantitative Meta-Analysis.FRONTIERS IN NEUROLOGY,9,9.
MLA Wang, Wenhui,et al."Altered Resting-State Functional Activity in Patients With Autism Spectrum Disorder: A Quantitative Meta-Analysis".FRONTIERS IN NEUROLOGY 9(2018):9.
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