CASIA OpenIR
KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People
Wang, Dawei1; Hu, Li1; Xu, Xinghua1; Ma, Xiangxing1; Li, Yi2; Liu, Yong3; Wang, Qing1; Zhuo, Chuanjun4
Source PublicationJOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN1079-5006
2019-11-01
Volume74Issue:11Pages:1725-1733
Corresponding AuthorZhuo, Chuanjun(chuanjunzhuotjmh@163.com)
AbstractGenetic factors play a critical role in the development of Alzheimer's disease (AD). Kidney and brain expressed protein (KIBRA) and apolipoprotein E (APOE) are involved in episodic memory performance and AD. However, the interactions between KIBRA and APOE on brain functional network connectivity (FNC) remain unknown in healthy older people. Using independent component analysis, we systematically investigated additive and epistatic interactions of KIBRA rs1707045 and APOE on FNC in 170 healthy older Chinese people of Han ethnicity. We found significant additive KIBRA-APOE interactions on brain FNC in the right medial prefrontal cortex, the posterior cingulate cortex in the default-mode network, and the dorsal anterior cingulate cortex in the salience network. We also found significant epistatic KIBRA-APOE interactions on brain FNC in the left superior frontal gyrus and left angular gyrus in default-mode network. No significant KIBRA-APOE interactions were detected in other brain resting-state networks. These findings suggest that healthy older people have additive and epistatic interactions of KIBRA and APOE gene variants, which modulate brain FNC and may partly elucidate their association with episodic memory performance and AD.
KeywordKIBRA APOE Resting-state network Genetic interaction MRI
DOI10.1093/gerona/glz004
WOS KeywordINFLUENCES EPISODIC MEMORY ; APOLIPOPROTEIN-E GENOTYPE ; RESTING-STATE NETWORKS ; E TYPE-4 ALLELE ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; POLYMORPHISM ; ASSOCIATION ; RISK ; HIPPOCAMPUS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81400890] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81871052] ; Shandong Provincial Key Research and Development Program[2017GSF218093] ; Shandong Provincial Key Research and Development Program[2017CXGC1502] ; Shandong Provincial Key Research and Development Program[2017CXGC1504] ; Shandong Provincial Science and Technology Major Project (Emerging Industry)[2015ZDXX0801A01] ; Fundamental Research Funds of Shandong University[2017JC013] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; Tianjin Health Bureau Foundation[2014KR02]
Funding OrganizationNational Natural Science Foundation of China ; Shandong Provincial Key Research and Development Program ; Shandong Provincial Science and Technology Major Project (Emerging Industry) ; Fundamental Research Funds of Shandong University ; Key Projects of the Natural Science Foundation of Tianjin, China ; Tianjin Health Bureau Foundation
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology ; Gerontology
WOS IDWOS:000491242600006
PublisherOXFORD UNIV PRESS INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26623
Collection中国科学院自动化研究所
Corresponding AuthorZhuo, Chuanjun
Affiliation1.Shangdong Univ, Dept Radiol, Qilu Hosp, Jinan, Shandong, Peoples R China
2.Shangdong Univ, Dept Neurol, Qilu Hosp, Jinan, Shandong, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Tianjin Anding Hosp, Dept Psychiat Neuroimaging Genet & Comorbid Lab P, 13 Liulin Rd, Tianjin 300222, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dawei,Hu, Li,Xu, Xinghua,et al. KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(11):1725-1733.
APA Wang, Dawei.,Hu, Li.,Xu, Xinghua.,Ma, Xiangxing.,Li, Yi.,...&Zhuo, Chuanjun.(2019).KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(11),1725-1733.
MLA Wang, Dawei,et al."KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.11(2019):1725-1733.
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