KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People

doi:10.1093/gerona/glz004

	KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People
	Wang, Dawei 1; Hu, Li 1; Xu, Xinghua 1; Ma, Xiangxing 1; Li, Yi 2; Liu, Yong3 ; Wang, Qing 1; Zhuo, Chuanjun 4
发表期刊	JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN	1079-5006
	2019-11-01
卷号	74 期号:11 页码:1725-1733
通讯作者	Zhuo, Chuanjun(chuanjunzhuotjmh@163.com)
摘要	Genetic factors play a critical role in the development of Alzheimer's disease (AD). Kidney and brain expressed protein (KIBRA) and apolipoprotein E (APOE) are involved in episodic memory performance and AD. However, the interactions between KIBRA and APOE on brain functional network connectivity (FNC) remain unknown in healthy older people. Using independent component analysis, we systematically investigated additive and epistatic interactions of KIBRA rs1707045 and APOE on FNC in 170 healthy older Chinese people of Han ethnicity. We found significant additive KIBRA-APOE interactions on brain FNC in the right medial prefrontal cortex, the posterior cingulate cortex in the default-mode network, and the dorsal anterior cingulate cortex in the salience network. We also found significant epistatic KIBRA-APOE interactions on brain FNC in the left superior frontal gyrus and left angular gyrus in default-mode network. No significant KIBRA-APOE interactions were detected in other brain resting-state networks. These findings suggest that healthy older people have additive and epistatic interactions of KIBRA and APOE gene variants, which modulate brain FNC and may partly elucidate their association with episodic memory performance and AD.
关键词	KIBRA APOE Resting-state network Genetic interaction MRI
DOI	10.1093/gerona/glz004
关键词[WOS]	INFLUENCES EPISODIC MEMORY ; APOLIPOPROTEIN-E GENOTYPE ; RESTING-STATE NETWORKS ; E TYPE-4 ALLELE ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; POLYMORPHISM ; ASSOCIATION ; RISK ; HIPPOCAMPUS
收录类别	SCI
语种	英语
资助项目	Tianjin Health Bureau Foundation[2014KR02] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; Fundamental Research Funds of Shandong University[2017JC013] ; Shandong Provincial Science and Technology Major Project (Emerging Industry)[2015ZDXX0801A01] ; Shandong Provincial Key Research and Development Program[2017CXGC1504] ; Shandong Provincial Key Research and Development Program[2017CXGC1502] ; Shandong Provincial Key Research and Development Program[2017GSF218093] ; National Natural Science Foundation of China[81871052] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81400890] ; National Natural Science Foundation of China[81400890] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81871052] ; Shandong Provincial Key Research and Development Program[2017GSF218093] ; Shandong Provincial Key Research and Development Program[2017CXGC1502] ; Shandong Provincial Key Research and Development Program[2017CXGC1504] ; Shandong Provincial Science and Technology Major Project (Emerging Industry)[2015ZDXX0801A01] ; Fundamental Research Funds of Shandong University[2017JC013] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; Tianjin Health Bureau Foundation[2014KR02]
项目资助者	National Natural Science Foundation of China ; Shandong Provincial Key Research and Development Program ; Shandong Provincial Science and Technology Major Project (Emerging Industry) ; Fundamental Research Funds of Shandong University ; Key Projects of the Natural Science Foundation of Tianjin, China ; Tianjin Health Bureau Foundation
WOS研究方向	Geriatrics & Gerontology
WOS类目	Geriatrics & Gerontology ; Gerontology
WOS记录号	WOS:000491242600006
出版者	OXFORD UNIV PRESS INC
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/26623
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Zhuo, Chuanjun
作者单位	1.Shangdong Univ, Dept Radiol, Qilu Hosp, Jinan, Shandong, Peoples R China 2.Shangdong Univ, Dept Neurol, Qilu Hosp, Jinan, Shandong, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Tianjin Anding Hosp, Dept Psychiat Neuroimaging Genet & Comorbid Lab P, 13 Liulin Rd, Tianjin 300222, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dawei,Hu, Li,Xu, Xinghua,et al. KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(11):1725-1733.
APA	Wang, Dawei.,Hu, Li.,Xu, Xinghua.,Ma, Xiangxing.,Li, Yi.,...&Zhuo, Chuanjun.(2019).KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(11),1725-1733.
MLA	Wang, Dawei,et al."KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.11(2019):1725-1733.