Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors

doi:10.1007/s00429-019-01924-7

	Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors
	Tang, Jie 1,2; Li, Yanjun 1,2; Xu, Jiayuan 1,2; Qin, Wen 1,2; Su, Qian 3,4; Xu, Qiang 1,2; Liu, Bing5 ; Jiang, Tianzi5 ; Yu, Chunshui 1,2
发表期刊	BRAIN STRUCTURE & FUNCTION
ISSN	1863-2653
	2019-11-01
卷号	224 期号:8 页码:2619-2630
通讯作者	Yu, Chunshui(chunshuiyu@tmu.edu.cn)
摘要	Catechol-O-methyltransferase (COMT) affects brain connectivity via modulating the dopamine system, with an expected greater effect of haplotypes than single-nucleotide polymorphism (SNP). The action pathway from COMT to dopamine to connectivity is theoretically dependent on the gene expression of dopamine receptors. Here, we aimed to investigate the impact of COMT haplotypes on brain functional connectivity density (FCD) in hundreds of healthy young subjects, and to disclose the association between the COMT-FCD statistical map and the spatial expression of the dopamine receptor genes. We found an inverted U-shaped modulation of COMT haplotypes on FCD in the left inferior parietal lobule that is mainly connected to the frontal and parietal cortices, with APS homozygotes exhibiting greater FCD than the other five groups. However, we failed to identify any significant effect of any SNP on FCD. Utilizing gene expression data collected from Allen human brain atlas, we found the COMT-FCD statistical map was significantly associated with the expression patterns of the dopamine receptor genes. Our results suggest that COMT haplotypes have greater impact on functional connectivity than a single genetic variation and that the association between COMT and functional connectivity may be dependent on the gene expression of dopamine receptors.
关键词	Allen human brain atlas COMT Functional connectivity density Functional magnetic resonance imaging Haplotype
DOI	10.1007/s00429-019-01924-7
关键词[WOS]	CATECHOL-O-METHYLTRANSFERASE ; GRAY-MATTER VOLUME ; MOTION ARTIFACT ; CONFOUND REGRESSION ; ICA-AROMA ; SCHIZOPHRENIA ; VARIANTS ; RISK ; POLYMORPHISM ; MODULATION
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[81301201] ; Natural Science Foundation of China[81501451] ; Natural Science Foundation of China[81425013] ; National Key Research and Development Program of China[2018YFC1314301] ; National Key Research and Development Program of China[2018YFC1314301] ; Natural Science Foundation of China[81425013] ; Natural Science Foundation of China[81501451] ; Natural Science Foundation of China[81301201]
项目资助者	National Key Research and Development Program of China ; Natural Science Foundation of China
WOS研究方向	Anatomy & Morphology ; Neurosciences & Neurology
WOS类目	Anatomy & Morphology ; Neurosciences
WOS记录号	WOS:000489147300003
出版者	SPRINGER HEIDELBERG
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/26652
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Yu, Chunshui
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China 3.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China 4.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 5.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Tang, Jie,Li, Yanjun,Xu, Jiayuan,et al. Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors[J]. BRAIN STRUCTURE & FUNCTION,2019,224(8):2619-2630.
APA	Tang, Jie.,Li, Yanjun.,Xu, Jiayuan.,Qin, Wen.,Su, Qian.,...&Yu, Chunshui.(2019).Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors.BRAIN STRUCTURE & FUNCTION,224(8),2619-2630.
MLA	Tang, Jie,et al."Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors".BRAIN STRUCTURE & FUNCTION 224.8(2019):2619-2630.