| Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors | |
Tang, Jie1,2; Li, Yanjun1,2; Xu, Jiayuan1,2; Qin, Wen1,2; Su, Qian3,4; Xu, Qiang1,2; Liu, Bing5 ; Jiang, Tianzi5; Yu, Chunshui1,2
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| Source Publication | BRAIN STRUCTURE & FUNCTION
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| ISSN | 1863-2653 |
| 2019-11-01 | |
| Volume | 224Issue:8Pages:2619-2630 |
| Corresponding Author | Yu, Chunshui(chunshuiyu@tmu.edu.cn) |
| Abstract | Catechol-O-methyltransferase (COMT) affects brain connectivity via modulating the dopamine system, with an expected greater effect of haplotypes than single-nucleotide polymorphism (SNP). The action pathway from COMT to dopamine to connectivity is theoretically dependent on the gene expression of dopamine receptors. Here, we aimed to investigate the impact of COMT haplotypes on brain functional connectivity density (FCD) in hundreds of healthy young subjects, and to disclose the association between the COMT-FCD statistical map and the spatial expression of the dopamine receptor genes. We found an inverted U-shaped modulation of COMT haplotypes on FCD in the left inferior parietal lobule that is mainly connected to the frontal and parietal cortices, with APS homozygotes exhibiting greater FCD than the other five groups. However, we failed to identify any significant effect of any SNP on FCD. Utilizing gene expression data collected from Allen human brain atlas, we found the COMT-FCD statistical map was significantly associated with the expression patterns of the dopamine receptor genes. Our results suggest that COMT haplotypes have greater impact on functional connectivity than a single genetic variation and that the association between COMT and functional connectivity may be dependent on the gene expression of dopamine receptors. |
| Keyword | Allen human brain atlas COMT Functional connectivity density Functional magnetic resonance imaging Haplotype |
| DOI | 10.1007/s00429-019-01924-7 |
| WOS Keyword | CATECHOL-O-METHYLTRANSFERASE ; GRAY-MATTER VOLUME ; MOTION ARTIFACT ; CONFOUND REGRESSION ; ICA-AROMA ; SCHIZOPHRENIA ; VARIANTS ; RISK ; POLYMORPHISM ; MODULATION |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFC1314301] ; Natural Science Foundation of China[81425013] ; Natural Science Foundation of China[81501451] ; Natural Science Foundation of China[81301201] ; National Key Research and Development Program of China[2018YFC1314301] ; Natural Science Foundation of China[81425013] ; Natural Science Foundation of China[81501451] ; Natural Science Foundation of China[81301201] |
| Funding Organization | National Key Research and Development Program of China ; Natural Science Foundation of China |
| WOS Research Area | Anatomy & Morphology ; Neurosciences & Neurology |
| WOS Subject | Anatomy & Morphology ; Neurosciences |
| WOS ID | WOS:000489147300003 |
| Publisher | SPRINGER HEIDELBERG |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/26652 |
| Collection | 脑网络组研究 |
| Corresponding Author | Yu, Chunshui |
| Affiliation | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China 3.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China 4.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 5.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Tang, Jie,Li, Yanjun,Xu, Jiayuan,et al. Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors[J]. BRAIN STRUCTURE & FUNCTION,2019,224(8):2619-2630. |
| APA | Tang, Jie.,Li, Yanjun.,Xu, Jiayuan.,Qin, Wen.,Su, Qian.,...&Yu, Chunshui.(2019).Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors.BRAIN STRUCTURE & FUNCTION,224(8),2619-2630. |
| MLA | Tang, Jie,et al."Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors".BRAIN STRUCTURE & FUNCTION 224.8(2019):2619-2630. |
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