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White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study
Cui Yue1,2,3; Dong Jiahao4; Yang Yongfeng5,6,7; Yu Hongyan5,6,7; Li Wenqiang5,6,7; Liu Yang4; Si Juanning4; Xie Sangma8; Sui Jing1,2,3,9; Lv Luxian5,6,7; Jiang Tianzi1,2,3,9,10,11
发表期刊JOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
2020
卷号260页码:281-286
通讯作者Lv Luxian(lvx928@126.com) ; Jiang Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要Background: White matter abnormalities have been implicated in mental disorders including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ); however, the shared and distinct white matter integrity across mental disorders is still unclear. Methods: A total of 290 participants (MDD = 85, BD = 42, SZ = 68, and healthy controls = 95) were included in the present study. Tract-based spatial statistics were performed to measure fractional anisotropy (FA) and characterize shared and distinguishing white matter changes across mental disorders. Results: We found that decreased FA converged across MDD, BD and SZ in the body and genu of the corpus callosum, bilateral anterior and posterior corona radiata, and right superior corona radiata. By contrast, diagnosis-specific effect was only found in MDD in the anterior portion of anterior corona radiata. Limitations: The small and imbalanced sample size, and possible confounding effects of medication. Conclusions: Our findings suggest that abnormally reduced white matter integrity in the interhemispheric and thalamocortical circuit could be consistently involved in the pathogenesis of MDD, BD and SZ.
DOI10.1016/j.jad.2019.09.029
关键词[WOS]PSYCHIATRIC-DISORDERS ; ABNORMALITIES ; INTEGRITY ; IDENTIFICATION ; INVENTORY ; ANXIETY ; BURDEN ; SCALE ; MANIA
收录类别SCI
语种英语
资助项目Natural Science Foundation of China[31771076] ; Natural Science Foundation of China[81671330] ; Open Program of Henan Key Laboratory of Biological Psychiatry[ZDSYS2018002] ; Cross Training (Shipei) Project of Beijing lnformation Science and Technology University ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC0904301] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Support Project for the Disciplinary Group of Psychology and Neuroscience, Xinxiang Medical University ; Natural Science Foundation of China[31771076] ; Natural Science Foundation of China[81671330] ; Open Program of Henan Key Laboratory of Biological Psychiatry[ZDSYS2018002] ; Cross Training (Shipei) Project of Beijing lnformation Science and Technology University ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC0904301] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Support Project for the Disciplinary Group of Psychology and Neuroscience, Xinxiang Medical University
项目资助者Natural Science Foundation of China ; Open Program of Henan Key Laboratory of Biological Psychiatry ; Cross Training (Shipei) Project of Beijing lnformation Science and Technology University ; High Scientific and Technological Research Fund of Xinxiang Medical University ; National Key Research and Development Program of China ; Medical Science and Technology Research Project of Henan Province ; Support Project for the Disciplinary Group of Psychology and Neuroscience, Xinxiang Medical University
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000490428300038
出版者ELSEVIER
七大方向——子方向分类脑网络分析
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/26658
专题脑网络组研究
通讯作者Lv Luxian; Jiang Tianzi
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Beijing Informat Sci & Technol Univ, Sch Instrumentat Sci & Optoelect Engn, Beijing, Peoples R China
5.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
6.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Henan, Peoples R China
8.Hangzhou Dianzi Univ, Coll Life Informat Sci & Instrument Engn, Hangzhou 310018, Zhejiang, Peoples R China
9.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
10.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
11.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
第一作者单位中国科学院自动化研究所;  模式识别国家重点实验室
通讯作者单位中国科学院自动化研究所;  模式识别国家重点实验室
推荐引用方式
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Cui Yue,Dong Jiahao,Yang Yongfeng,et al. White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,260:281-286.
APA Cui Yue.,Dong Jiahao.,Yang Yongfeng.,Yu Hongyan.,Li Wenqiang.,...&Jiang Tianzi.(2020).White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study.JOURNAL OF AFFECTIVE DISORDERS,260,281-286.
MLA Cui Yue,et al."White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study".JOURNAL OF AFFECTIVE DISORDERS 260(2020):281-286.
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