CASIA OpenIR
Differentiation of atypical non-functional pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma using CT based radiomics
He, Ming1; Liu, Zhenyu2,3,5; Lin, Yusong4; Wan, Jianzhong4; Li, Juan1; Xu, Kai1; Wang, Yun1; Jin, Zhengyu1; Tian, Jie2,3,5,6,7; Xue, Huadan1
Source PublicationEUROPEAN JOURNAL OF RADIOLOGY
ISSN0720-048X
2019-08-01
Volume117Pages:102-111
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Xue, Huadan(bjdanna95@hotmail.com)
AbstractPurpose: To develop and validate an effective model to differentiate NF-pNET from PDAC. Materials and methods: Between July 2014 and December 2017, 147 patients (80 patients with PDAC and 67 patients with atypical NF-pNET) with pathology results and enhanced CT were consecutively enrolled and chronologically divided into primary and validation cohorts. Three models were built to differentiate atypical NF-pNET from PDAC, including a model based on radiomic signature alone, one based on clinicoradiological features alone and one that integrated the two. The diagnostic performance of the three models was estimated and compared with the area under the receiver operating characteristic curve (AUC) in the validation cohort. A nomogram was used to represent the model with the best performance, and the associated calibration was also assessed. Results: In the validation cohort, the AUC for differential diagnosis was 0.884 with the integrated model, which was significantly improved over that of the model based on clinicoradiological features (AUC = 0.775, p value = 0.004) and was comparable to that of the model based on the radiomic signature (AUC = 0.873, p value = 0.512). The nomogram representing the integrated model achieved good discrimination performances in both the primary and validation cohorts, with C-indices of 0.960 and 0.884, respectively. Conclusion: The integrated model outperformed the model based on clinicoradiological features alone and was comparable to the model based on the radiomic signature alone with respect to the differential diagnosis of atypical NF-pNET and PDAC. The nomogram achieved an optimal preoperative, noninvasive differential diagnosis between atypical pNET and PDAC, which can better inform therapeutic choice in clinical practice.
KeywordPancreatic ductal carcinoma Neuroendocrine tumor Multidetector computed tomography Radiomics Differential diagnosis
DOI10.1016/j.ejrad.2019.05.024
WOS KeywordIMAGING MIMICS ; DIAGNOSIS ; PREDICTION ; MANAGEMENT ; GUIDELINES ; CARCINOMA ; SURVIVAL ; MDCT
Indexed BySCI
Language英语
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000475337200014
PublisherELSEVIER IRELAND LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26832
Collection中国科学院自动化研究所
Corresponding AuthorTian, Jie; Xue, Huadan
Affiliation1.Peking Union Med Coll Hosp Beijing, Dept Radiol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Zhengzhou Univ, Software Technol Sch, Zhengzhou, Henan, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Precis Med, Sch Med, Beijing 100191, Peoples R China
7.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian 710126, Shaanxi, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
He, Ming,Liu, Zhenyu,Lin, Yusong,et al. Differentiation of atypical non-functional pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma using CT based radiomics[J]. EUROPEAN JOURNAL OF RADIOLOGY,2019,117:102-111.
APA He, Ming.,Liu, Zhenyu.,Lin, Yusong.,Wan, Jianzhong.,Li, Juan.,...&Xue, Huadan.(2019).Differentiation of atypical non-functional pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma using CT based radiomics.EUROPEAN JOURNAL OF RADIOLOGY,117,102-111.
MLA He, Ming,et al."Differentiation of atypical non-functional pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma using CT based radiomics".EUROPEAN JOURNAL OF RADIOLOGY 117(2019):102-111.
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