Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect

doi:10.1007/s00330-018-5814-3

	Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect
	Du, Yang1,2,3 ; Jin, Yinhua 4; Sun, Wei1,4 ; Fang, Junjie 4; Zheng, Jianjun 4; Tian, Jie 1,2,3,4,5
发表期刊	EUROPEAN RADIOLOGY
ISSN	0938-7994
	2019-08-01
卷号	29 期号:8 页码:4294-4302
通讯作者	Zheng, Jianjun(zhjjnb2@163.com) ; Tian, Jie(tian@ieee.org)
摘要	ObjectivesThis review describes the current status and progress of immune checkpoint targets for imaging of malignancies. Immune checkpoint blockade holds great potential for cancer treatment, and clinical implementation into routine is very rapidly progressing. Therefore, it is an urgent need to become familiar with the vocabulary of immunotherapy and with the evaluation of immune checkpoint and related treatments through noninvasive molecular imaging. Currently, immune target-associated imaging mainly includes PET, SPECT, optical imaging, and MRI. Each imaging method has its own inherent strengths and weaknesses in reflecting tumor morphology and physiology. PD-1, PD-L1, CTLA-4, and LAG-3 are the most commonly considered targets. In this review, the current status and progress of molecular imaging of immune checkpoint targets are discussed.ConclusionMolecular imaging is likely to become a major tool for monitoring immunotherapy. It can help in selecting patients who are suitable for immunotherapy, and also monitor the tumor response.Key Points center dot Immune checkpoint blockade holds great promise for the treatment of different malignant tumors.center dot Molecular imaging can identify the expression of immune checkpoint targets in the tumor microenvironment at the molecular and cellular levels, and therefore helps selecting potential responders, suitable for specific immunotherapy.center dot Molecular imaging can also monitor immunotherapeutic effects, and therefore participates in the evaluation of tumor response to treatment.
关键词	Cancer Immunotherapy Molecular imaging Immune checkpoint target
DOI	10.1007/s00330-018-5814-3
关键词[WOS]	PD-L1 EXPRESSION ; INFILTRATING LYMPHOCYTES ; CANCER-IMMUNOTHERAPY ; RADIOTRACER ; INHIBITORS ; BLOCKADE ; ANTIBODY
收录类别	SCI
语种	英语
资助项目	Key Scientific and Technological Special Project of Ningbo City[2015C50004] ; Public Welfare Technology Application Research Project of Zhejiang Province[2017C35003] ; Key R&D project of Zhejiang Province[2017C03042] ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province[WKJ-ZJ-1807] ; Bei jing Municipal Science and Technology Commission[Z161100002616022] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; Ministry of Science and Technology of China[2014CB748600] ; Ministry of Science and Technology of China[2015CB755500] ; Ministry of Science and Technology of China[2016YFA0201401] ; Ministry of Science and Technology of China[2106YFC0103702] ; Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2106YFC0103702] ; Ministry of Science and Technology of China[2016YFA0201401] ; Ministry of Science and Technology of China[2015CB755500] ; Ministry of Science and Technology of China[2014CB748600] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81470083] ; Bei jing Municipal Science and Technology Commission[Z161100002616022] ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province[WKJ-ZJ-1807] ; Key R&D project of Zhejiang Province[2017C03042] ; Public Welfare Technology Application Research Project of Zhejiang Province[2017C35003] ; Key Scientific and Technological Special Project of Ningbo City[2015C50004]
项目资助者	Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Bei jing Municipal Science and Technology Commission ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province ; Key R&D project of Zhejiang Province ; Public Welfare Technology Application Research Project of Zhejiang Province ; Key Scientific and Technological Special Project of Ningbo City
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000473737100037
出版者	SPRINGER
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/26835
专题	中国科学院分子影像重点实验室
通讯作者	Zheng, Jianjun; Tian, Jie
作者单位	1.Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 4.Ningbo 2 Hosp, Dept Radiol, Xibei St 41, Ningbo 315010, Zhejiang, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Du, Yang,Jin, Yinhua,Sun, Wei,et al. Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect[J]. EUROPEAN RADIOLOGY,2019,29(8):4294-4302.
APA	Du, Yang,Jin, Yinhua,Sun, Wei,Fang, Junjie,Zheng, Jianjun,&Tian, Jie.(2019).Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect.EUROPEAN RADIOLOGY,29(8),4294-4302.
MLA	Du, Yang,et al."Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect".EUROPEAN RADIOLOGY 29.8(2019):4294-4302.