CASIA OpenIR
Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect
Du, Yang1,2,3; Jin, Yinhua4; Sun, Wei1,4; Fang, Junjie4; Zheng, Jianjun4; Tian, Jie1,2,3,4,5
Source PublicationEUROPEAN RADIOLOGY
ISSN0938-7994
2019-08-01
Volume29Issue:8Pages:4294-4302
Corresponding AuthorZheng, Jianjun(zhjjnb2@163.com) ; Tian, Jie(tian@ieee.org)
AbstractObjectivesThis review describes the current status and progress of immune checkpoint targets for imaging of malignancies. Immune checkpoint blockade holds great potential for cancer treatment, and clinical implementation into routine is very rapidly progressing. Therefore, it is an urgent need to become familiar with the vocabulary of immunotherapy and with the evaluation of immune checkpoint and related treatments through noninvasive molecular imaging. Currently, immune target-associated imaging mainly includes PET, SPECT, optical imaging, and MRI. Each imaging method has its own inherent strengths and weaknesses in reflecting tumor morphology and physiology. PD-1, PD-L1, CTLA-4, and LAG-3 are the most commonly considered targets. In this review, the current status and progress of molecular imaging of immune checkpoint targets are discussed.ConclusionMolecular imaging is likely to become a major tool for monitoring immunotherapy. It can help in selecting patients who are suitable for immunotherapy, and also monitor the tumor response.Key Points center dot Immune checkpoint blockade holds great promise for the treatment of different malignant tumors.center dot Molecular imaging can identify the expression of immune checkpoint targets in the tumor microenvironment at the molecular and cellular levels, and therefore helps selecting potential responders, suitable for specific immunotherapy.center dot Molecular imaging can also monitor immunotherapeutic effects, and therefore participates in the evaluation of tumor response to treatment.
KeywordCancer Immunotherapy Molecular imaging Immune checkpoint target
DOI10.1007/s00330-018-5814-3
WOS KeywordPD-L1 EXPRESSION ; INFILTRATING LYMPHOCYTES ; CANCER-IMMUNOTHERAPY ; RADIOTRACER ; INHIBITORS ; BLOCKADE ; ANTIBODY
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2106YFC0103702] ; Ministry of Science and Technology of China[2016YFA0201401] ; Ministry of Science and Technology of China[2015CB755500] ; Ministry of Science and Technology of China[2014CB748600] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81470083] ; Bei jing Municipal Science and Technology Commission[Z161100002616022] ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province[WKJ-ZJ-1807] ; Key R&D project of Zhejiang Province[2017C03042] ; Public Welfare Technology Application Research Project of Zhejiang Province[2017C35003] ; Key Scientific and Technological Special Project of Ningbo City[2015C50004]
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; Bei jing Municipal Science and Technology Commission ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province ; Key R&D project of Zhejiang Province ; Public Welfare Technology Application Research Project of Zhejiang Province ; Key Scientific and Technological Special Project of Ningbo City
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000473737100037
PublisherSPRINGER
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26835
Collection中国科学院自动化研究所
Corresponding AuthorZheng, Jianjun; Tian, Jie
Affiliation1.Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Ningbo 2 Hosp, Dept Radiol, Xibei St 41, Ningbo 315010, Zhejiang, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Du, Yang,Jin, Yinhua,Sun, Wei,et al. Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect[J]. EUROPEAN RADIOLOGY,2019,29(8):4294-4302.
APA Du, Yang,Jin, Yinhua,Sun, Wei,Fang, Junjie,Zheng, Jianjun,&Tian, Jie.(2019).Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect.EUROPEAN RADIOLOGY,29(8),4294-4302.
MLA Du, Yang,et al."Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect".EUROPEAN RADIOLOGY 29.8(2019):4294-4302.
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