CASIA OpenIR
Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks
Niu, Weikun1,2,4,5; Huang, Xuhui1,2,3,4; Xu, Kaibin1,2,4,5; Jiang, Tianzi1,2,4,5; Yu, Shan1,2,4,5
Source PublicationNEUROSCIENCE
ISSN0306-4522
2019-08-01
Volume412Pages:190-206
Corresponding AuthorYu, Shan(shan.yu@nlpr.ia.ac.cn)
AbstractSpatially separated brain areas interact with each other to form networks with coordinated activities, supporting various brain functions. Interaction structures among brain areas have been widely investigated through pairwise measures. However, interactions among multiple (e.g., triple and quadruple) areas cannot be reduced to pairwise interactions. Such higher order interactions (HOIs), e.g., exclusive-or (XOR) operation, are widely implemented in computation systems and are crucial for effective information processing. However, it is currently unclear whether any HOIs are present in large-scale brain functional networks when subjects are executing specific tasks. Here we analyzed functional magnetic resonance imaging (fMRI) data collected from human subjects executing various perceptual, motor, and cognitive tasks. We found that HOI strength in the macroscopic functional networks was very weak for all tasks, suggesting that major brain activities do not rely on HOIs on the macroscopic level at the timescale of hundreds of milliseconds. These weak HOIs during tasks were further investigated with a neural network model activated by external inputs, which suggested that weak pairwise interactions among brain areas organized the system without involving HOIs. Taken together, these results demonstrated the dominance of pairwise interactions in organizing coordinated activities among different brain areas to support various brain functions. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
Keywordtask state fMRI pairwise correlation functional network neural network model
DOI10.1016/j.neuroscience.2019.05.011
WOS KeywordHIGHER-ORDER INTERACTIONS ; NETWORKS ; CORTEX ; MICROSTIMULATION ; INTEGRATION ; COMPETITION ; MECHANISM ; COHERENCE
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0105203] ; Natural Science Foundation of China[81471368] ; Natural Science Foundation of China[11505283] ; Natural Science Foundation of China[91732305] ; Natural Science Foundation of China[31620103905] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB32040200] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB32030200] ; Hundred-Talent Program of CAS ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SMC019]
Funding OrganizationNational Key Research and Development Program of China ; Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) ; Hundred-Talent Program of CAS ; Key Research Program of Frontier Sciences, CAS
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000474688600016
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/26844
Collection中国科学院自动化研究所
Corresponding AuthorYu, Shan
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Niu, Weikun,Huang, Xuhui,Xu, Kaibin,et al. Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks[J]. NEUROSCIENCE,2019,412:190-206.
APA Niu, Weikun,Huang, Xuhui,Xu, Kaibin,Jiang, Tianzi,&Yu, Shan.(2019).Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks.NEUROSCIENCE,412,190-206.
MLA Niu, Weikun,et al."Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks".NEUROSCIENCE 412(2019):190-206.
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