| ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI | |
Li, Jiachen1; Jin, Dan2,3,4 ; Li, Ang2,3,4; Liu, Bing2,3,4,5; Song, Chengyuan6; Wang, Pan7,8; Wang, Dawei9; Xu, Kaibin2,3; Yang, Hongwei10; Yao, Hongxiang11; Zhou, Bo8; Bejanin, Alexandre12; Chetelat, Gael12; Han, Tong13; Lu, Jie10; Wang, Qing9; Yu, Chunshui14; Zhang, Xinqing1; Zhou, Yuying7; Zhang, Xi8; Jiang, Tianzi2,3,4,5; Liu, Yong2,3,4,5; Han, Ying1,15,16,17
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| Source Publication | SCIENCE BULLETIN
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| ISSN | 2095-9273 |
| 2019-07-30 | |
| Volume | 64Issue:14Pages:998-1010 |
| Corresponding Author | Liu, Yong(yliu@nlpr.ia.ac.cn) ; Han, Ying(hanying@xwh.ccmu.edu.cn) |
| Abstract | Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P < 0.05, Bonferroni corrected) between the normalized amplitude index and Mini-Mental State Examination scores were found in the identified brain regions, which indicates that the altered brain activity was associated with cognitive decline in the patients. Multivariate analysis and leave-one-siteout cross-validation led to a 78.49% prediction accuracy for single-patient classification. The altered activity patterns of the identified brain regions were largely correlated with the FDG-PET results from another independent study. These results emphasized the impaired brain activity to provide a robust and reproducible imaging signature of AD. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
| Keyword | Brain spontaneous activity Multisite Biomarkers Leave-one-site-out cross-validation Alzheimer's disease |
| DOI | 10.1016/j.scib.2019.04.034 |
| WOS Keyword | MILD COGNITIVE IMPAIRMENT ; RESTING-STATE FMRI ; POSTERIOR CINGULATE CORTEX ; LOW-FREQUENCY FLUCTUATIONS ; GRAY-MATTER ANOMALIES ; FUNCTIONAL CONNECTIVITY ; BRAIN ACTIVITY ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2016YFC1305904] ; National Key Research and Development Program of China[2016YFC1306300] ; National Natural Science Foundation of China[81871438] ; National Natural Science Foundation of China[61633018] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81471120] ; National Natural Science Foundation of China[61431012] ; National Natural Science Foundation of China[81430037] ; Strategic Priority Research Program (B) of Chinese Academy of Sciences[XDB32020200] ; Beijing Municipal Commission of Health and Family Planning[PXM2019_ 026283_ 000002] ; National Key Research and Development Program of China[2016YFC1305904] ; National Key Research and Development Program of China[2016YFC1306300] ; National Natural Science Foundation of China[81871438] ; National Natural Science Foundation of China[61633018] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81471120] ; National Natural Science Foundation of China[61431012] ; National Natural Science Foundation of China[81430037] ; Strategic Priority Research Program (B) of Chinese Academy of Sciences[XDB32020200] ; Beijing Municipal Commission of Health and Family Planning[PXM2019_ 026283_ 000002] |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program (B) of Chinese Academy of Sciences ; Beijing Municipal Commission of Health and Family Planning |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000483302400009 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/27200 |
| Collection | 脑网络组研究 |
| Corresponding Author | Liu, Yong; Han, Ying |
| Affiliation | 1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing 100190, Peoples R China 6.Shandong Univ, Qilu Hosp, Dept Neurol, Jinan 250012, Shandong, Peoples R China 7.Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300350, Peoples R China 8.Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr & Gerontol, Beijing 100853, Peoples R China 9.Qilu Hosp, Dept Radiol, Jinan 250012, Shandong, Peoples R China 10.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 11.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 12.Univ Caen Normandie, Univ Normandie, INSERM, GIP Cyceron,UMR S U1237, F-14000 Caen, France 13.Tianjin Huanhu Hosp, Dept Radiol, Tianjin 300350, Peoples R China 14.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 15.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China 16.Beijing Inst Geriatr, Beijing 100053, Peoples R China 17.Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Jiachen,Jin, Dan,Li, Ang,et al. ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI[J]. SCIENCE BULLETIN,2019,64(14):998-1010. |
| APA | Li, Jiachen.,Jin, Dan.,Li, Ang.,Liu, Bing.,Song, Chengyuan.,...&Han, Ying.(2019).ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI.SCIENCE BULLETIN,64(14),998-1010. |
| MLA | Li, Jiachen,et al."ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI".SCIENCE BULLETIN 64.14(2019):998-1010. |
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