Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer | |
Fan, Li1; Fang, MengJie2,3; Tu, WenTing1; Zhang, Di1; Wang, Yun1; Zhou, Xiuxiu1; Xia, Yi1; Li, ZhaoBin4; Liu, ShiYuan1 | |
发表期刊 | ACADEMIC RADIOLOGY |
ISSN | 1076-6332 |
2019-09-01 | |
卷号 | 26期号:9页码:1253-1261 |
摘要 | Objectives: To evaluate the predictive value of radiomics features on the distant metastasis (DM) of stage I nonsmall cell lung cancer (NSCLC) preoperatively, by comparing with clinical characteristics and CT morphological features, and to screen the important prognostic predictors. Methods: One hundred ninety-four stage I NSCLC patients were retrospectively enrolled, DM free survival (DMFS) was evaluated. The consensus clustering analysis was used to build the radiomics signatures in the primary cohort and validated in the validation cohort. The univariate survival analysis was performed in clinical characteristics, CT morphological features and radiomics signatures, respectively. Cox model was performed and C-index was calculated. Results: There were 25 patients (12.9%) with DM. The median DMFS was 15 months. Three hundred thirteen radiomics features were selected, then classified into five groups, two subtypes (I and II) with each group. The RS1 showed the best prognostic ability with C-index of 0.355(95% confidence interval [CI], 0.269-0.442; p < 0.001). The histological type exhibited a good prognostic ability with C-index of 0.123 (95% CI, 0.000-0.305; p < 0.001) for DMFS. Cox model showed RS1(hazard ratio [HR] 18.025, 95% CI 2.366-137.340), pleural indentation sign (HR 2.623, 95% CI 1.070-6.426) and histological type (HR 4.461, 95% CI 1.783-11.162) were the independent prognostic factors (p < 0.05). Conclusion: Radiomics provided a new modality for the distant metastatic prediction of stage I NSCLC. Patients with type II of RS1, pleural indentation sign and nonadenocarcinoma indicated the high probability of postsurgical DM. |
关键词 | Lung Nonsmall cell lung cancer Tomography X-ray computed Computational biology Prognosis |
DOI | 10.1016/j.acra.2018.11.004 |
关键词[WOS] | TUMOR HETEROGENEITY ; TNM CLASSIFICATION ; PROGNOSTIC VALUE ; 8TH EDITION ; FEATURES ; REPRODUCIBILITY ; GROUPINGS ; REVISION ; NODULES |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81370035] ; Youth Fund of the National Natural Science Foundation of China[81501618] ; National Natural Science Foundation of China[81871321] ; National Key R&D Program of China[2017YFC1308703] ; National Key R&D Program of China[2016YFE0103000] ; National Key R&D Program of China[2016YFE0103000] ; National Key R&D Program of China[2017YFC1308703] ; National Natural Science Foundation of China[81871321] ; Youth Fund of the National Natural Science Foundation of China[81501618] ; National Natural Science Foundation of China[81370035] |
WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000482544300017 |
出版者 | ELSEVIER SCIENCE INC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/27245 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Li, ZhaoBin; Liu, ShiYuan |
作者单位 | 1.Second Mil Med Univ, Changzheng Hosp, Dept Radiol, 415 Fengyang Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiat Oncol, 600 Yishan Rd, Shanghai 200233, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Li,Fang, MengJie,Tu, WenTing,et al. Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer[J]. ACADEMIC RADIOLOGY,2019,26(9):1253-1261. |
APA | Fan, Li.,Fang, MengJie.,Tu, WenTing.,Zhang, Di.,Wang, Yun.,...&Liu, ShiYuan.(2019).Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer.ACADEMIC RADIOLOGY,26(9),1253-1261. |
MLA | Fan, Li,et al."Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer".ACADEMIC RADIOLOGY 26.9(2019):1253-1261. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Radiomics Signature (858KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论