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Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer
Fan, Li1; Fang, MengJie2,3; Tu, WenTing1; Zhang, Di1; Wang, Yun1; Zhou, Xiuxiu1; Xia, Yi1; Li, ZhaoBin4; Liu, ShiYuan1
Source PublicationACADEMIC RADIOLOGY
ISSN1076-6332
2019-09-01
Volume26Issue:9Pages:1253-1261
Abstract

Objectives: To evaluate the predictive value of radiomics features on the distant metastasis (DM) of stage I nonsmall cell lung cancer (NSCLC) preoperatively, by comparing with clinical characteristics and CT morphological features, and to screen the important prognostic predictors. Methods: One hundred ninety-four stage I NSCLC patients were retrospectively enrolled, DM free survival (DMFS) was evaluated. The consensus clustering analysis was used to build the radiomics signatures in the primary cohort and validated in the validation cohort. The univariate survival analysis was performed in clinical characteristics, CT morphological features and radiomics signatures, respectively. Cox model was performed and C-index was calculated. Results: There were 25 patients (12.9%) with DM. The median DMFS was 15 months. Three hundred thirteen radiomics features were selected, then classified into five groups, two subtypes (I and II) with each group. The RS1 showed the best prognostic ability with C-index of 0.355(95% confidence interval [CI], 0.269-0.442; p < 0.001). The histological type exhibited a good prognostic ability with C-index of 0.123 (95% CI, 0.000-0.305; p < 0.001) for DMFS. Cox model showed RS1(hazard ratio [HR] 18.025, 95% CI 2.366-137.340), pleural indentation sign (HR 2.623, 95% CI 1.070-6.426) and histological type (HR 4.461, 95% CI 1.783-11.162) were the independent prognostic factors (p < 0.05). Conclusion: Radiomics provided a new modality for the distant metastatic prediction of stage I NSCLC. Patients with type II of RS1, pleural indentation sign and nonadenocarcinoma indicated the high probability of postsurgical DM.

KeywordLung Nonsmall cell lung cancer Tomography X-ray computed Computational biology Prognosis
DOI10.1016/j.acra.2018.11.004
WOS KeywordTUMOR HETEROGENEITY ; TNM CLASSIFICATION ; PROGNOSTIC VALUE ; 8TH EDITION ; FEATURES ; REPRODUCIBILITY ; GROUPINGS ; REVISION ; NODULES
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81370035] ; Youth Fund of the National Natural Science Foundation of China[81501618] ; National Natural Science Foundation of China[81871321] ; National Key R&D Program of China[2017YFC1308703] ; National Key R&D Program of China[2016YFE0103000] ; National Key R&D Program of China[2016YFE0103000] ; National Key R&D Program of China[2017YFC1308703] ; National Natural Science Foundation of China[81871321] ; Youth Fund of the National Natural Science Foundation of China[81501618] ; National Natural Science Foundation of China[81370035]
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000482544300017
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/27245
Collection中国科学院分子影像重点实验室
Corresponding AuthorLi, ZhaoBin; Liu, ShiYuan
Affiliation1.Second Mil Med Univ, Changzheng Hosp, Dept Radiol, 415 Fengyang Rd, Shanghai 200233, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiat Oncol, 600 Yishan Rd, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Fan, Li,Fang, MengJie,Tu, WenTing,et al. Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer[J]. ACADEMIC RADIOLOGY,2019,26(9):1253-1261.
APA Fan, Li.,Fang, MengJie.,Tu, WenTing.,Zhang, Di.,Wang, Yun.,...&Liu, ShiYuan.(2019).Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer.ACADEMIC RADIOLOGY,26(9),1253-1261.
MLA Fan, Li,et al."Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer".ACADEMIC RADIOLOGY 26.9(2019):1253-1261.
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