CASIA OpenIR
Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis
Liu, Xiaoli1,3; Zheng, Jianjun6; Sun, Wei6; Zhao, Xiao1; Li, Yao1; Gong, Ningqiang1; Wang, Yanyun3; Ma, Xiaowei1; Zhang, Tingbin5; Zhao, Ling-Yun7; Hou, Yayi8,9; Wu, Zhibing10; Du, Yang4; Fan, Haiming5; Tian, Jie4; Liang, Xing-Jie1,2
Source PublicationACS NANO
ISSN1936-0851
2019-08-01
Volume13Issue:8Pages:8811-8825
Corresponding AuthorDu, Yang(yang.du@ia.ac.cn) ; Fan, Haiming(fanhm@nwu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Liang, Xing-Jie(liangxj@nanoctr.cn)
AbstractCancer metastasis is a serious concern and a major reason for treatment failure. Herein, we have reported the development of an effective and safe nanotherapeutic strategy that can eradicate primary tumors, inhibit metastasizing to lung, and control the metastasis and growth of distant tumors. Briefly, ferrimagnetic vortex-domain iron oxide nanoring (FVIO)-mediated mild magnetic hyperthermia caused calreticulin (CRT) expression on the 4T1 breast cancer cells. The CRT expression transmitted an "eat-me" signal and promoted phagocytic uptake of cancer cells by the immune system to induce an efficient immunogenic cell death, further leading to the macrophage polarization. This mild thermotherapy promoted 88% increase of CD8(+) cytotoxic T lymphocyte infiltration in distant tumors and triggered immunotherapy by effectively sensitizing tumors to the PD-L1 checkpoint blockade. The percentage of CD8(+) cytotoxic T lymphocytes can be further increased from 55.4% to 64.5% after combining with PD-L1 blockade. Moreover, the combination treatment also inhibited the immunosuppressive response of the tumor, evidenced by significant down-regulation of myeloid-derived suppressor cells (MDSCs). Our results revealed that the FWD-mediated mild magnetic hyperthermia can activate the host immune systems and efficiently cooperate with PD-L1 blockade to inhibit the potential metastatic spreading as well as the growth of distant tumors.
Keywordferrimagnetic vortex-domain iron oxide nanorings mild magnetic hyperthermia PD-L1 blockade immunotherapy immunological effect cancer metastasis
DOI10.1021/acsnano.9b01979
WOS KeywordTUMOR-INFILTRATING LYMPHOCYTES ; IMMUNE CHECKPOINT BLOCKADE ; NEGATIVE BREAST-CANCER ; IRON-OXIDE NANOCUBES ; PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; ANTITUMOR IMMUNITY ; PROSTATE-CANCER ; NANOPARTICLES ; IMMUNOTHERAPY
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation[31630027] ; Natural Science Foundation[31430031] ; NSFC-DFG[31761133013] ; Ministry of Science and Technology of China[2017YFA0205200] ; CAS[XDA09030301] ; National Natural Science Foundation of China[81571809] ; National Natural Science Foundation of China[81771981] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81227901]
Funding OrganizationNatural Science Foundation ; NSFC-DFG ; Ministry of Science and Technology of China ; CAS ; National Natural Science Foundation of China
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000484077800031
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/27321
Collection中国科学院自动化研究所
Corresponding AuthorDu, Yang; Fan, Haiming; Tian, Jie; Liang, Xing-Jie
Affiliation1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11,First North Rd, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Northwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
5.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China
6.Univ Chinese Acad Sci, Ningbo 2 Hosp, Hwa Mei Hosp, Dept Radiol, Ningbo 315010, Zhejiang, Peoples R China
7.Tsinghua Univ, Sch Mat Sci & Engn, Key Lab Adv Mat, Beijing 100084, Peoples R China
8.Nanjing Univ, Med Sch, Div Immunol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
9.Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China
10.Zhejiang Hosp, Dept Radiat Oncol, Hangzhou 310013, Zhejiang, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Xiaoli,Zheng, Jianjun,Sun, Wei,et al. Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis[J]. ACS NANO,2019,13(8):8811-8825.
APA Liu, Xiaoli.,Zheng, Jianjun.,Sun, Wei.,Zhao, Xiao.,Li, Yao.,...&Liang, Xing-Jie.(2019).Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis.ACS NANO,13(8),8811-8825.
MLA Liu, Xiaoli,et al."Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis".ACS NANO 13.8(2019):8811-8825.
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