Progression of cognitive decline before and after incident stroke

doi:10.1212/WNL.0000000000007716

	Progression of cognitive decline before and after incident stroke
	Zheng, Fanfan1,2 ; Yan, Li 3; Zhong, Baoliang 4; Yang, Zhenchun 3; Xie, Wuxiang 3,5
发表期刊	NEUROLOGY
ISSN	0028-3878
	2019-07-02
卷号	93 期号:1 页码:E20-E28
通讯作者	Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn)
摘要	Objective To determine the trajectory of cognitive decline before and after incident stroke. Methods By using data from the English Longitudinal Study of Ageing, we studied 9,278 participants without dementia with no history of stroke who underwent cognitive assessment at baseline (wave 1) and at least 1 other time point (waves 2-7). We used linear mixed models to analyze repeated measures and longitudinal data. Results Among the 9,278 participants (56.8% women, mean age 63.1 +/- 10.3 years), 471 (5.1%) incident stroke events were identified. Compared with stroke-free participants, multivariable-adjusted rates of prestroke cognitive decline in global cognition, memory, semantic fluency, and temporal orientation of participants who later experienced an incident stroke were increased by -0.029, -0.016, -0.022, and -0.024 SD/y, respectively. Among the 471 stroke survivors, the multivariable-adjusted acute changes in the 4 cognitive domains were -0.257, -0.150, -0.121, and -0.272 SD, respectively. In the years after stroke, global cognition declined over time and was steeper than its prestroke slope, that is, by -0.064 SD/y after multivariable adjustment. The rates of memory, semantic fluency, and temporal orientation decline were -0.046, -0.033, and -0.037 SD/y, respectively. Conclusions Accelerated prestroke cognitive decline and poststroke cognitive decline were associated with incident stroke over a follow-up period of 12 years. Attention should be paid to the long-term cognitive problems of stroke survivors, and intervention and management of major vascular risk factors should start from early life or midlife to reduce the risk of cerebrovascular disease and the associated cognitive impairment.
DOI	10.1212/WNL.0000000000007716
关键词[WOS]	1ST-EVER STROKE ; RISK-FACTORS ; IMPAIRMENT ; DEMENTIA ; DISEASE ; PREDICTORS ; ASSOCIATION ; MECHANISMS
收录类别	SCI
语种	英语
资助项目	Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804] ; Beijing Natural Science Foundation[7182108] ; National Natural Science Foundation of China[81601176] ; National Natural Science Foundation of China[81601176] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804]
项目资助者	National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology
WOS记录号	WOS:000480781000003
出版者	LIPPINCOTT WILLIAMS & WILKINS
七大方向——子方向分类	脑网络分析
引用统计	被引频次：64[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/27537
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Xie, Wuxiang
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.UCL, Inst Cognit Neurosci, London, England 3.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Dept Geriatr Psychiat, Wuhan, Hubei, Peoples R China 5.Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zheng, Fanfan,Yan, Li,Zhong, Baoliang,et al. Progression of cognitive decline before and after incident stroke[J]. NEUROLOGY,2019,93(1):E20-E28.
APA	Zheng, Fanfan,Yan, Li,Zhong, Baoliang,Yang, Zhenchun,&Xie, Wuxiang.(2019).Progression of cognitive decline before and after incident stroke.NEUROLOGY,93(1),E20-E28.
MLA	Zheng, Fanfan,et al."Progression of cognitive decline before and after incident stroke".NEUROLOGY 93.1(2019):E20-E28.