Institutional Repository of Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients | |
Jing, Rixing1,2; Li, Peng3,4; Ding, Zengbo5,6; Lin, Xiao3,4,7,8; Zhao, Rongjiang9; Shi, Le3,4; Yan, Hao3,4; Liao, Jinmin3,4; Zhuo, Chuanjun10,11; Lu, Lin3,4,5,6,7,8; Fan, Yong12 | |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
2019-09-01 | |
卷号 | 40期号:13页码:3930-3939 |
通讯作者 | Fan, Yong(yong.fan@uphs.upenn.edu) |
摘要 | Schizophrenia (SCZ) patients and their unaffected first-degree relatives (FDRs) share similar functional neuroanatomy. However, it remains largely unknown to what extent unaffected FDRs with functional neuroanatomy patterns similar to patients can be identified at an individual level. In this study, we used a multivariate pattern classification method to learn informative large-scale functional networks (FNs) and build classifiers to distinguish 32 patients from 30 healthy controls and to classify 34 FDRs as with or without FNs similar to patients. Four informative FNs-the cerebellum, default mode network (DMN), ventral frontotemporal network, and posterior DMN with parahippocampal gyrus-were identified based on a training cohort and pattern classifiers built upon these FNs achieved a correct classification rate of 83.9% (sensitivity 87.5%, specificity 80.0%, and area under the receiver operating characteristic curve [AUC] 0.914) estimated based on leave-one-out cross-validation for the training cohort and a correct classification rate of 77.5% (sensitivity 72.5%, specificity 82.5%, and AUC 0.811) for an independent validation cohort. The classification scores of the FDRs and patients were negatively correlated with their measures of cognitive function. FDRs identified by the classifiers as having SCZ patterns were similar to the patients, but significantly different from the controls and FDRs with normal patterns in terms of their cognitive measures. These results demonstrate that the pattern classifiers built upon the informative FNs can serve as biomarkers for quantifying brain alterations in SCZ and help to identify FDRs with FN patterns and cognitive impairment similar to those of SCZ patients. |
关键词 | cognitive impairment functional networks machine learning pattern classification resting-state functional magnetic resonance imaging unaffected first-degree relatives |
DOI | 10.1002/hbm.24678 |
关键词[WOS] | ULTRA-HIGH-RISK ; WORKING-MEMORY ; PSYCHOSIS ; FMRI ; CONNECTIVITY ; DEFICITS ; SIBLINGS ; CLASSIFICATION ; INDIVIDUALS ; DYSFUNCTION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Basic Research Program of China[2015CB856400] ; National Institutes of Health[EB022573] ; National Institutes of Health[MH112070] ; National Natural Science Foundation of China[81501158] ; National Natural Science Foundation of China[61473296] ; National Basic Research Program of China[2015CB856400] ; National Institutes of Health[EB022573] ; National Institutes of Health[MH112070] ; National Natural Science Foundation of China[81501158] ; National Natural Science Foundation of China[61473296] |
项目资助者 | National Basic Research Program of China ; National Institutes of Health ; National Natural Science Foundation of China |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000478645900016 |
出版者 | WILEY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/27755 |
专题 | 模式识别国家重点实验室 |
通讯作者 | Fan, Yong |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Peking Univ, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Key Lab Mental Hlth, Beijing, Peoples R China 4.Peking Univ, Peking Univ Hosp 6, Beijing, Peoples R China 5.Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China 6.Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China 7.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China 8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China 9.Peking Univ, Beijing Hui Long Guan Hosp, Dept Alcohol & Drug Dependence, Beijing, Peoples R China 10.Nankai Univ, Affiliated Tianjin Anding Hosp, Tianjin Mental Hlth Ctr, Tianjin, Peoples R China 11.Tianjin Med Univ, Dept Psychiat, Tianjin, Peoples R China 12.Univ Penn, Dept Radiol, Perelman Sch Med, Philadelphia, PA 19104 USA |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Jing, Rixing,Li, Peng,Ding, Zengbo,et al. Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients[J]. HUMAN BRAIN MAPPING,2019,40(13):3930-3939. |
APA | Jing, Rixing.,Li, Peng.,Ding, Zengbo.,Lin, Xiao.,Zhao, Rongjiang.,...&Fan, Yong.(2019).Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients.HUMAN BRAIN MAPPING,40(13),3930-3939. |
MLA | Jing, Rixing,et al."Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients".HUMAN BRAIN MAPPING 40.13(2019):3930-3939. |
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