Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study

doi:10.1016/j.jpsychires.2019.06.009

	Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study
	Guo, Fan 1,2; Zhu, Yuan-Qiang 1; Li, Chen 1; Wang, Xing-Rui 1; Wang, Hua-Ning 4; Liu, Wen-Ming 4; Wang, Liu-Xian 1,3; Tian, Ping 1; Kang, Xiao-Wei 1; Cui, Long-Biao 1,5; Xi, Yi-Bin 1; Yin, Hong 1
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
	2019-09-01
卷号	116 页码:126-132
通讯作者	Xi, Yi-Bin(xiyibin@fmmu.edu.cn) ; Yin, Hong(yinhong@fmmu.edu.cn)
摘要	Despite evidence of structural brain abnormalities in schizophrenia, the current study aimed to explore the effects of antipsychotic treatment on gray matter (GM) volume using structural magnetic resonance imaging (MRI) and investigate the relationship between brain structure and treatment response. The GM volumes of 33 patients with first-episode schizophrenia were calculated with voxel-based morphometry (VBM), with 33 matched healthy controls. Longitudinal volume changes within subjects after 4-month antipsychotic treatment were also evaluated. Correlation between volumetric changes and clinical symptoms derived from the Positive and Negative Syndrome Scale (PANSS) were further investigated. Compared with healthy controls, decreased GM volumes in the frontal gyrus were observed in schizophrenia patients. After 4-month treatment, patients showed significantly decreased GM volume primarily in the bilateral frontal, temporal and left parietal brain regions. In addition, the GM volume changes of the left postcentral gyrus was positively correlated with negative symptoms improvement, and the correlation analysis revealed the total PANSS scores changes were associated with GM volume changes in the right inferior frontal gyrus and the right superior temporal gyrus. Besides, non-responders had reduced GM volume in the bilateral middle frontal gyrus and the right superior frontal gyrus compared with responders and healthy controls. Our results suggest that the abnormality in the right frontal gyrus exists in the early stage of schizophrenia. Moreover, the relationship between antipsychotics and structural changes was identified. The GM volume might have the potential to reflect the symptom improvement in schizophrenia patients. And MRI may assist in predicting the antipsychotic treatment response in first-episode schizophrenia patients.
关键词	Schizophrenia Voxel-based morphometry Antipsychotics Magnetic resonance imaging First-episode Gray matter volume
DOI	10.1016/j.jpsychires.2019.06.009
关键词[WOS]	PROGRESSIVE BRAIN CHANGES ; SUPERIOR TEMPORAL GYRUS ; CORTICAL THICKNESS ; NEUROLEPTIC-NAIVE ; CHRONIC EXPOSURE ; METAANALYSIS ; PSYCHOSIS ; ABNORMALITIES ; HALOPERIDOL ; OLANZAPINE
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81400952] ; National Natural Science Foundation of China[81571651] ; National Natural Science Foundation of China[81601474] ; National Natural Science Foundation of China[81801772] ; National Basic Research Program of China[2015CB856403] ; Key Research and Development Program of Shaanxi Province[2017ZDXM-SF-048] ; National Natural Science Foundation of China[81400952] ; National Natural Science Foundation of China[81571651] ; National Natural Science Foundation of China[81601474] ; National Natural Science Foundation of China[81801772] ; National Basic Research Program of China[2015CB856403] ; Key Research and Development Program of Shaanxi Province[2017ZDXM-SF-048]
项目资助者	National Natural Science Foundation of China ; National Basic Research Program of China ; Key Research and Development Program of Shaanxi Province
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000475996500018
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/27776
专题	中国科学院分子影像重点实验室
通讯作者	Xi, Yi-Bin; Yin, Hong
作者单位	1.Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China 4.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China 5.Fourth Mil Med Univ, Sch Med Psychol, Dept Clin Psychol, Xian 710032, Shaanxi, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Guo, Fan,Zhu, Yuan-Qiang,Li, Chen,et al. Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2019,116:126-132.
APA	Guo, Fan.,Zhu, Yuan-Qiang.,Li, Chen.,Wang, Xing-Rui.,Wang, Hua-Ning.,...&Yin, Hong.(2019).Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study.JOURNAL OF PSYCHIATRIC RESEARCH,116,126-132.
MLA	Guo, Fan,et al."Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: A longitudinal voxel-based morphometric study".JOURNAL OF PSYCHIATRIC RESEARCH 116(2019):126-132.