CASIA OpenIR
Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer
Sun, Wei1,2; Du, Yang2,3; Liang, Xiaolong4; Yu, Chunyao1; Fang, Junjie1; Lu, Wei1; Guo, Xiuyu1; Tian, Jie2,3,5,6; Jin, Yinhua1; Zheng, Jianjun1
Source PublicationBIOMATERIALS
ISSN0142-9612
2019-10-01
Volume217Pages:13
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Jin, Yinhua(jyh-mri@163.com) ; Zheng, Jianjun(zhjjnb2@163.com)
AbstractBreast cancer is characterized by high aggression, poor prognosis, and high recurrence rate. Early detection and specific targeted treatment with less toxicity are the ultimate goals for breast cancer therapy. To improve antitumor therapeutic effects, we developed a novel polypyrrole nanoparticle using the near infrared dye IRDye800CW with camptothecin (CPT)-conjugated hyaluronic acid (HA) shell (PPy@CPT-HA-IRDye800CW) and performed a photothermal therapy (PTT), along with chemotherapy, guided by fluorescence and photo acoustic dual-modality imaging, in combination with immunotherapy. Irradiation with near infrared (NIR) light offered a strong PTT effect and promoted CPT drug release in tumors. Moreover, we found that chemo-photothermal therapy with PPy@CPT-HA-IRDye800CW NPs, in combination with immune checkpoint inhibitor anti-PD-L1 immunotherapy, synergistically enhanced the anti-tumor immune response, thereby eliminating primary breast cancer and preventing tumor metastases and recurrences in 4T1 tumor-bearing mice. This approach may provide important clues for the clinical management of breast cancer and other malignant tumors.
KeywordBreast cancer Polypyrrole nanoparticle Hyaluronic acid Photothermal therapy Triple-combination therapy
DOI10.1016/j.biomaterials.2019.119264
WOS KeywordIMMUNE CHECKPOINT BLOCKADE ; INFRARED PHOTOTHERMAL THERAPY ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; EXPRESSION ; IMMUNOTHERAPY ; INDUCTION ; EFFICIENT ; DISEASE ; PD-L1
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China, China[2017YFA0205200] ; National Natural Science Foundation of China, China[81871514] ; National Natural Science Foundation of China, China[81470083] ; National Natural Science Foundation of China, China[81227901] ; National Natural Science Foundation of China, China[81571810] ; National Natural Science Foundation of China, China[81771846] ; National Natural Science Foundation of China, China[81822022] ; Chinese Academy of Sciences, China[XDB02060010] ; International Innovation Team of CAS, China[20140491524] ; Beijing Municipal Commission of Science & Technology, China[Z161100002616022] ; Science Research Fund of National Health and Family Planning Commission Major Project of Medical and Health Science and Technology in Zhejiang Province, China[WKJ-ZJ-1807] ; Key R&D project of Zhejiang Province, China[2017C03042] ; Peking University Third Hospital, China[BYSY2015023]
Funding OrganizationNational Key Research and Development Program of China, China ; National Natural Science Foundation of China, China ; Chinese Academy of Sciences, China ; International Innovation Team of CAS, China ; Beijing Municipal Commission of Science & Technology, China ; Science Research Fund of National Health and Family Planning Commission Major Project of Medical and Health Science and Technology in Zhejiang Province, China ; Key R&D project of Zhejiang Province, China ; Peking University Third Hospital, China
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000477786200014
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/27804
Collection中国科学院自动化研究所
Corresponding AuthorTian, Jie; Jin, Yinhua; Zheng, Jianjun
Affiliation1.Univ Chinese Acad Sci, Dept Radiol, Hwa Mei Hosp, Ningbo 2 Hosp, 41 Xibei St, Ningbo 315010, Zhejiang, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing 100191, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
6.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
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Sun, Wei,Du, Yang,Liang, Xiaolong,et al. Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer[J]. BIOMATERIALS,2019,217:13.
APA Sun, Wei.,Du, Yang.,Liang, Xiaolong.,Yu, Chunyao.,Fang, Junjie.,...&Zheng, Jianjun.(2019).Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer.BIOMATERIALS,217,13.
MLA Sun, Wei,et al."Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer".BIOMATERIALS 217(2019):13.
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