CASIA OpenIR  > 中国科学院分子影像重点实验室
Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging
Zhang, Lu1; Zhou, Hongyu2; Gu, Dongsheng2; Tian, Jie2; Zhang, Bin3,4; Dong, Di2; Mo, Xiaokai1; Liu, Jing5; Luo, Xiaoning1; Pei, Shufang1; Dong, Yuhao1; Huang, Wenhui1; Chen, Qiuyin3,4; Liang, Changhong1; Lian, Zhouyang1; Zhang, Shuixing1
Source PublicationJOURNAL OF CANCER
ISSN1837-9664
2019
Volume10Issue:18Pages:4217-4225
Corresponding AuthorLian, Zhouyang() ; Zhang, Shuixing(zsx7515@jnu.edu.cn)
AbstractBackground: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred and forty patients were randomly divided into a training cohort (n = 80) and a validation cohort (n = 60). A total of 970 radiomic features were extracted from pretreatment magnetic resonance (MR) images of NPC patients from May 2007 to December 2013. Univariate and multivariate analyses were used for selecting radiomic features associated with local recurrence, and multivariate analyses was used for building radiomic nomogram. Results: Eight contrast-enhanced T1-weighted (CET1-w) image features and seven T2-weighted (T2-w) image features were selected to build a Cox proportional hazard model in the training cohort, respectively. The radiomic nomogram, which combined radiomic features and multiple clinical variables, had a good evaluation ability (C-index: 0.74 [95% CI: 0.58, 0.85]) in the validation cohort. The radiomic nomogram successfully categorized those patients into low- and high-risk groups with significant differences in the rate of local recurrence-free survival (P <0.05). Conclusions: This study demonstrates that MR imaging-based radiomics can be used as an aid tool for the evaluation of local recurrence, in order to develop tailored treatment targeting specific characteristics of individual patients.
KeywordMagnetic Resonance Imaging Nasopharyngeal Carcinoma Local Recurrence Radiomic Feature Nomogram
DOI10.7150/jca.33345
WOS KeywordLYMPH-NODE METASTASIS ; INTENSITY-MODULATED RADIOTHERAPY ; POSITRON-EMISSION-TOMOGRAPHY ; DISTANT METASTASIS ; PREOPERATIVE PREDICTION ; INTRATUMOR HETEROGENEITY ; TUMOR HETEROGENEITY ; COMPUTED-TOMOGRAPHY ; PROGNOSTIC MODEL ; TEXTURE ANALYSIS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81571664] ; National Natural Science Foundation of China[81871323] ; National Natural Science Foundation of China[81801665] ; National Natural Science Foundation of Guangdong Province[2018B030311024] ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission[201707010328] ; China Postdoctoral Science Foundation[2016M600145] ; National Natural Science Foundation of China[81571664] ; National Natural Science Foundation of China[81871323] ; National Natural Science Foundation of China[81801665] ; National Natural Science Foundation of Guangdong Province[2018B030311024] ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission[201707010328] ; China Postdoctoral Science Foundation[2016M600145]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of Guangdong Province ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission ; China Postdoctoral Science Foundation
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000477730000007
PublisherIVYSPRING INT PUBL
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/27827
Collection中国科学院分子影像重点实验室
Corresponding AuthorLian, Zhouyang; Zhang, Shuixing
Affiliation1.Guangdong Acad Med Sci, Dept Radiol, Guangdong Prov Peoples Hosp, 106 Zhongshan Er Rd, Guangzhou 510080, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
3.Jinan Univ, Med Imaging Ctr, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
4.Jinan Univ, Inst Mol & Funct Imaging, Guangzhou, Guangdong, Peoples R China
5.Guizhou Med Univ, Dept Radiol Guiyang, Affiliated Hosp, Guiyang, Guizhou, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Lu,Zhou, Hongyu,Gu, Dongsheng,et al. Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging[J]. JOURNAL OF CANCER,2019,10(18):4217-4225.
APA Zhang, Lu.,Zhou, Hongyu.,Gu, Dongsheng.,Tian, Jie.,Zhang, Bin.,...&Zhang, Shuixing.(2019).Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging.JOURNAL OF CANCER,10(18),4217-4225.
MLA Zhang, Lu,et al."Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging".JOURNAL OF CANCER 10.18(2019):4217-4225.
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