CASIA OpenIR
Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers
Yuan, Kai1,2,3,4,5; Zhao, Meng1,3; Yu, Dahua3; Manza, Peter2; Volkow, Nora D.2,6; Wang, Gene-Jack2; Tian, Jie1,3,7
Source PublicationNEUROPSYCHOPHARMACOLOGY
ISSN0893-133X
2018-11-01
Volume43Issue:12Pages:2452-2458
Corresponding AuthorYuan, Kai(kyuan@xidian.edu.cn)
AbstractStriatal circuit dysfunction is implicated in smoking behaviors and lapses during abstinence attempts. However, little is known about whether the structural connectivity of striatal tracts can be used to predict abstinence-induced craving and lapses. The tract strengths of striatal circuits were compared in 53 male nicotine-dependent cigarette smokers and 58 matched nonsmokers, using seed-based classification by diffusion tensor imaging (DTI) probabilistic tractography with 10 a priori target masks. A 12-h abstinence procedure was then employed, after which 31 individuals abstained and 22 lapsed. Linear regression and binary logistic regression was conducted to test whether the tract strength of frontostriatal circuits was associated with craving changes in abstainers and predicted lapse in smokers. Compared with nonsmokers, in the left hemisphere, smokers showed weaker tract strength in striatum-medial orbitofrontal cortex (mOFC), striatum-ventral lateral prefrontal cortex (vlPFC), striatum-inferior frontal gyrus (IFG) and striatum-posterior cingulate cortex (PCC) (Bonferroni corrected, p < 0.05/20 = 0.0025). In abstainers, the abstinence-induced increases in craving were associated with the tract strength of the left striatum-mOFC and striatum-vlPFC. The tract strength of left striatum-dorsolateral PFC (dlPFC) predicted lapse in smokers with an accuracy of 68.3%. These results provide system-level insights into the weaker tract strength of frontostriatal circuits in male smokers and their potential roles as neuroimaging markers for abstinence-induced craving and risk of lapse. Future studies in female smokers are needed to determine if this generalizes across genders.
DOI10.1038/s41386-018-0182-x
WOS KeywordSTATE FUNCTIONAL CONNECTIVITY ; CIGARETTE-SMOKING ; PREFRONTAL CORTEX ; RESTING-STATE ; COGNITIVE CONTROL ; DOPAMINE RELEASE ; FRONTOSTRIATAL CONNECTIVITY ; SEX-DIFFERENCES ; CUE REACTIVITY ; YOUNG SMOKERS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81871426] ; National Natural Science Foundation of China[81871430] ; National Natural Science Foundation of China[81571751] ; National Natural Science Foundation of China[81571753] ; National Natural Science Foundation of China[61771266] ; National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[81701780] ; Fundamental Research Funds for the Central Universities[JB151204] ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJYT-17-B11] ; Natural Science Foundation of Inner Mongolia[2017MS(LH) 0814] ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region[NJZY17262] ; Innovation Fund Project of Inner Mongolia University of Science and Technology[2015QNGG03] ; National Natural Science Foundation of Shaanxi Province[2018JM7075] ; US National Institutes of Health[Y1AA3009]
Funding OrganizationNational Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Natural Science Foundation of Inner Mongolia ; program of Science and Technology in Universities of Inner Mongolia Autonomous Region ; Innovation Fund Project of Inner Mongolia University of Science and Technology ; National Natural Science Foundation of Shaanxi Province ; US National Institutes of Health
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000446868600017
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/28125
Collection中国科学院自动化研究所
Corresponding AuthorYuan, Kai
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.NIAAA, NIH, Bethesda, MD 20892 USA
3.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
5.Guangxi Normal Univ, Guangxi Key Lab Multisource Informat Min & Secur, Guilin 541001, Peoples R China
6.NIDA, NIH, Bethesda, MD 20892 USA
7.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Zhao, Meng,Yu, Dahua,et al. Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers[J]. NEUROPSYCHOPHARMACOLOGY,2018,43(12):2452-2458.
APA Yuan, Kai.,Zhao, Meng.,Yu, Dahua.,Manza, Peter.,Volkow, Nora D..,...&Tian, Jie.(2018).Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers.NEUROPSYCHOPHARMACOLOGY,43(12),2452-2458.
MLA Yuan, Kai,et al."Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers".NEUROPSYCHOPHARMACOLOGY 43.12(2018):2452-2458.
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