CASIA OpenIR
A novel plectin/integrin-targeted bispecific molecular probe for magnetic Check tat resonance/near-infrared imaging of pancreatic cancer
Wang, Qian1,2,3; Yan, Hao3,4; Jin, Yushen3; Wang, Zihua5; Huang, Wenhui3; Qiu, Jia3; Kang, Feiyu4; Wang, Kun3; Zhao, Xinming1,2; Tian, Jie3
Source PublicationBIOMATERIALS
ISSN0142-9612
2018-11-01
Volume183Pages:173-184
Corresponding AuthorWang, Kun(kun.wang@ia.ac.cn) ; Zhao, Xinming(xinmingzh2017@yeah.net) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies with poor patient outcomes often resulting from delayed diagnosis. Therefore, early diagnosis can lead to a better prognosis and improved outcomes. In this study, we have developed a novel conjugate complex of plectin/integrin-targeted bispecific molecular probe, termed Gd-Cy7-PTP/RGD, to be used for magnetic resonance/near-infrared imaging (MRI/NIRF) of pancreatic cancer in vivo. This bispecific molecular probe comprises four parts: Gd(III) for MRI, cyanine 7 (Cy7) for NIRF, the peptide PTP for binding to plectin-1 specifically overexpressed on the surface of PDAC cells, and the peptide RGD for targeting integrin widely expressed on pancreatic duct epithelial cells and angiogenesis. Remarkably, the combination of PTP and RGD greatly increased the targeting efficiency in vitro and in vivo compared to that of either single peptide. Moreover, such bispecific molecular probes target pancreatic neoplasms and angiogenesis simultaneously, producing a "multi-level" targeting effect confirmed by immunofluorescence testing in vitro and in vivo. Under the guidance of MRI/NIRF dual-modality imaging, NIRF-guided delineation of surgical margins during operations was successfully achieved in orthotopic pancreatic cancer. This study promotes further exploration of bispecific molecular probes for clinical application.
KeywordBispecific peptides Early diagnosis Molecular imaging Pancreatic cancer Theranostics
DOI10.1016/j.biomaterials.2018.08.048
WOS KeywordIN-VIVO ; DUCTAL ADENOCARCINOMA ; INTEGRIN ; THERAPY ; ALPHA-V-BETA-6 ; NANOPARTICLES ; METASTASIS ; STATISTICS ; CARCINOMA ; PATHWAY
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81671757] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFA0201401] ; National Key Research and Development Program of China[2106YFC0103702] ; CAMS Innovation Fund for Medical Sciences[2016-12M-1-001] ; National Natural Science Foundation of China[81671757] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFA0201401] ; National Key Research and Development Program of China[2106YFC0103702] ; CAMS Innovation Fund for Medical Sciences[2016-12M-1-001]
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; CAMS Innovation Fund for Medical Sciences
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000447116600016
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/28141
Collection中国科学院自动化研究所
Corresponding AuthorWang, Kun; Zhao, Xinming; Tian, Jie
Affiliation1.Chinese Acad Med Sci, Dept Imaging Diag Natl Canc Ctr, Canc Hosp, Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Tsinghua Univ, Grad Sch Shenzhen, Sch Mat Sci & Engn, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qian,Yan, Hao,Jin, Yushen,et al. A novel plectin/integrin-targeted bispecific molecular probe for magnetic Check tat resonance/near-infrared imaging of pancreatic cancer[J]. BIOMATERIALS,2018,183:173-184.
APA Wang, Qian.,Yan, Hao.,Jin, Yushen.,Wang, Zihua.,Huang, Wenhui.,...&Tian, Jie.(2018).A novel plectin/integrin-targeted bispecific molecular probe for magnetic Check tat resonance/near-infrared imaging of pancreatic cancer.BIOMATERIALS,183,173-184.
MLA Wang, Qian,et al."A novel plectin/integrin-targeted bispecific molecular probe for magnetic Check tat resonance/near-infrared imaging of pancreatic cancer".BIOMATERIALS 183(2018):173-184.
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