Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation

doi:10.1007/s00330-019-06452-w

	Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation
	Mo, Xiaokai 1,2; Wu, Xiangjun 3,4; Dong, Di3,4 ; Guo, Baoliang 1; Liang, Changhong 1; Luo, Xiaoning 1,5; Zhang, Bin 6; Zhang, Lu 1; Dong, Yuhao 1,2; Lian, Zhouyang 1; Liu, Jing 1; Pei, Shufang 1; Huang, Wenhui 1; Ouyang, Fusheng 1; Tian, Jie 3,4,7; Zhang, Shuixing 6
发表期刊	EUROPEAN RADIOLOGY
ISSN	0938-7994
	2020-02-01
卷号	30 期号:2 页码:833-843
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Zhang, Shuixing(shui7515@126.com)
摘要	Purpose To develop a radiomics-based model to stratify the risk of early progression (local/regional recurrence or metastasis) among patients with hypopharyngeal cancer undergoing chemoradiotherapy and modify their pretreatment plans. Materials and methods We randomly assigned 113 patients into two cohorts: training (n = 80) and validation (n = 33). The radiomic significant features were selected in the training cohort using least absolute shrinkage and selection operator and Akaike information criterion methods, and they were used to build the radiomic model. The concordance index (C-index) was applied to evaluate the model's prognostic performance. A Kaplan-Meier analysis and the log-rank test were used to assess risk stratification ability of models in predicting progression. A nomogram was plotted to predict individual risk of progression. Results Composed of four significant features, the radiomic model showed good performance in stratifying patients into high- and low-risk groups of progression in both the training and validation cohorts (log-rank test, p = 0.00016, p = 0.0063, respectively). Peripheral invasion and metastasis were selected as significant clinical variables. The combined radiomic-clinical model showed good discriminative performance, with C-indices 0.804 (95% confidence interval (CI), 0.688-0.920) and 0.756 (95% CI, 0.605-0.907) in the training and validation cohorts, respectively. The median progression-free survival (PFS) in the high-risk group was significantly shorter than that in the low-risk group in the training (median PFS, 9.5 m and 19.0 m, respectively; p [log-rank] < 0.0001) and validation (median PFS, 11.3 m and 22.5 m, respectively; p [log-rank] = 0.0063) cohorts. Conclusions A radiomics-based model was established to predict the risk of progression in hypopharyngeal cancer with chemoradiotherapy.
关键词	Head and neck cancer Hypopharynx Chemoradiotherapy Recurrence Prognosis
DOI	10.1007/s00330-019-06452-w
关键词[WOS]	LOCALLY ADVANCED HEAD ; TEXTURAL FEATURES ; SALVAGE TREATMENT ; NECK-CANCER ; OROPHARYNGEAL ; CHEMOTHERAPY ; PET ; MANAGEMENT ; TRENDS ; IMAGES
收录类别	SCI
语种	英语
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000511977900017
出版者	SPRINGER
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/28575
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Zhang, Shuixing
作者单位	1.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China 2.Shantou Univ, Coll Med, Shantou, Guangdong, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 5.Guangdong Acad Med Sci, Dept Otolaryngol Head & Neck Surg, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China 6.Jinan Univ, Affiliated Hosp 1, Dept Radiol, 613 Huangpu West Rd, Guangzhou 510627, Guangdong, Peoples R China 7.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Mo, Xiaokai,Wu, Xiangjun,Dong, Di,et al. Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation[J]. EUROPEAN RADIOLOGY,2020,30(2):833-843.
APA	Mo, Xiaokai.,Wu, Xiangjun.,Dong, Di.,Guo, Baoliang.,Liang, Changhong.,...&Zhang, Shuixing.(2020).Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation.EUROPEAN RADIOLOGY,30(2),833-843.
MLA	Mo, Xiaokai,et al."Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation".EUROPEAN RADIOLOGY 30.2(2020):833-843.