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A common hub for sleep and motor control in the substantia nigra | |
Liu, Danqian1; Li, Weifu2; Ma, Chenyan1; Zheng, Weitong1; Yao, Yuanyuan1; Tso, Chak Foon1; Zhong, Peng1; Chen, Xi2; Song, Jun Ho3; Choi, Woochul3; Paik, Se-Bum3; Han, Hua2; Dan, Yang1 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
2020-01-24 | |
卷号 | 367期号:6476页码:440-+ |
摘要 | The arousal state of the brain covaries with the motor state of the animal. How these state changes are coordinated remains unclear. We discovered that sleep-wake brain states and motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr). Analysis of mouse home-cage behavior identified four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randomly but primarily between neighboring states. The glutamic acid decarboxylase 2 but not the parvalbumin subset of SNr gamma-aminobutyric acid (GABA)-releasing (GABAergic) neurons was preferentially active in states of low motor activity and arousal. Their activation or inactivation biased the direction of natural behavioral transitions and promoted or suppressed sleep, respectively. These GABAergic neurons integrate wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through extensive collateral projections. |
关键词 | sleep and motor control substantia nigra behavior analysis |
DOI | 10.1126/science.aaz0956 |
关键词[WOS] | GABAERGIC NEURONS ; CIRCUITS ; ORGANIZATION ; DROSOPHILA ; PATHWAYS ; MIDBRAIN ; BEHAVIOR ; INPUTS ; GABA |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Howard Hughes Medical Institute ; Howard Hughes Medical Institute |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000509810200041 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/28593 |
专题 | 脑图谱与类脑智能实验室_微观重建与智能分析 |
通讯作者 | Dan, Yang |
作者单位 | 1.Univ Calif Berkeley, Howard Hughes Med Inst, Helen Wills Neurosci Inst, Div Neurobiol,Dept Mol & Cell Biol, Berkeley, CA 94720 USA 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea |
推荐引用方式 GB/T 7714 | Liu, Danqian,Li, Weifu,Ma, Chenyan,et al. A common hub for sleep and motor control in the substantia nigra[J]. SCIENCE,2020,367(6476):440-+. |
APA | Liu, Danqian.,Li, Weifu.,Ma, Chenyan.,Zheng, Weitong.,Yao, Yuanyuan.,...&Dan, Yang.(2020).A common hub for sleep and motor control in the substantia nigra.SCIENCE,367(6476),440-+. |
MLA | Liu, Danqian,et al."A common hub for sleep and motor control in the substantia nigra".SCIENCE 367.6476(2020):440-+. |
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A Common Hub for Sle(2023KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
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