Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer | |
You, Huijuan1,2; Shang, Wenting2; Min, Xiangde1; Weinreb, Jeffrey3; Li, Qiubai4; Leapman, Michael5; Wang, Liang1; Tian, Jie2,6 | |
发表期刊 | SCIENCE ADVANCES |
ISSN | 2375-2548 |
2020-02-01 | |
卷号 | 6期号:6页码:14 |
通讯作者 | Shang, Wenting(wenting.shang@ia.ac.cn) ; Wang, Liang(wang6@tjh.tjmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
摘要 | Nerve density is associated with prostate cancer (PCa) aggressiveness and prognosis. Thus far, no visualization methods have been developed to assess nerve density of PCa in vivo. We compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs), which achieved the nerve density visualization of PCa with high sensitivity and high specificity, and facilitated assessment of nerve density and aggressiveness of PCa using magnetic resonance imaging and magnetic particle imaging. Moreover, PSN NPs facilitated targeted therapy for PCa. PSN NPs increased the survival rate of mice with orthotopic PCa to 83.3% and decreased nerve densities and proliferation indexes by more than twofold compared with the control groups. The present study, thus, developed a technology to visualize the nerve density of PCa and facilitate targeted neural drug delivery to tumors to efficiently inhibit PCa progression. Our study provides a potential basis for clinical imaging and therapeutic interventions targeting nerves in PCa. |
DOI | 10.1126/sciadv.aax6040 |
关键词[WOS] | ESTRO-SIOG GUIDELINES ; SUPERPARAMAGNETIC NANOPARTICLES ; RAT ; SENSITIVITY ; RESOLUTION ; PROBES |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200] |
项目资助者 | National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000512902300010 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/28597 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Shang, Wenting; Wang, Liang; Tian, Jie |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Radiol, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Yale Univ, Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA 4.UT Southwestern Med Ctr, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA 5.Yale Univ, Sch Med, Dept Urol, New Haven, CT 06520 USA 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China |
第一作者单位 | 中国科学院分子影像重点实验室 |
通讯作者单位 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | You, Huijuan,Shang, Wenting,Min, Xiangde,et al. Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer[J]. SCIENCE ADVANCES,2020,6(6):14. |
APA | You, Huijuan.,Shang, Wenting.,Min, Xiangde.,Weinreb, Jeffrey.,Li, Qiubai.,...&Tian, Jie.(2020).Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer.SCIENCE ADVANCES,6(6),14. |
MLA | You, Huijuan,et al."Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer".SCIENCE ADVANCES 6.6(2020):14. |
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