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Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer
You, Huijuan1,2; Shang, Wenting2; Min, Xiangde1; Weinreb, Jeffrey3; Li, Qiubai4; Leapman, Michael5; Wang, Liang1; Tian, Jie2,6
发表期刊SCIENCE ADVANCES
ISSN2375-2548
2020-02-01
卷号6期号:6页码:14
通讯作者Shang, Wenting(wenting.shang@ia.ac.cn) ; Wang, Liang(wang6@tjh.tjmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要Nerve density is associated with prostate cancer (PCa) aggressiveness and prognosis. Thus far, no visualization methods have been developed to assess nerve density of PCa in vivo. We compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs), which achieved the nerve density visualization of PCa with high sensitivity and high specificity, and facilitated assessment of nerve density and aggressiveness of PCa using magnetic resonance imaging and magnetic particle imaging. Moreover, PSN NPs facilitated targeted therapy for PCa. PSN NPs increased the survival rate of mice with orthotopic PCa to 83.3% and decreased nerve densities and proliferation indexes by more than twofold compared with the control groups. The present study, thus, developed a technology to visualize the nerve density of PCa and facilitate targeted neural drug delivery to tumors to efficiently inhibit PCa progression. Our study provides a potential basis for clinical imaging and therapeutic interventions targeting nerves in PCa.
DOI10.1126/sciadv.aax6040
关键词[WOS]ESTRO-SIOG GUIDELINES ; SUPERPARAMAGNETIC NANOPARTICLES ; RAT ; SENSITIVITY ; RESOLUTION ; PROBES
收录类别SCI
语种英语
资助项目National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200]
项目资助者National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000512902300010
出版者AMER ASSOC ADVANCEMENT SCIENCE
七大方向——子方向分类医学影像处理与分析
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/28597
专题中国科学院分子影像重点实验室
通讯作者Shang, Wenting; Wang, Liang; Tian, Jie
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Radiol, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Yale Univ, Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA
4.UT Southwestern Med Ctr, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
5.Yale Univ, Sch Med, Dept Urol, New Haven, CT 06520 USA
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
第一作者单位中国科学院分子影像重点实验室
通讯作者单位中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
You, Huijuan,Shang, Wenting,Min, Xiangde,et al. Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer[J]. SCIENCE ADVANCES,2020,6(6):14.
APA You, Huijuan.,Shang, Wenting.,Min, Xiangde.,Weinreb, Jeffrey.,Li, Qiubai.,...&Tian, Jie.(2020).Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer.SCIENCE ADVANCES,6(6),14.
MLA You, Huijuan,et al."Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer".SCIENCE ADVANCES 6.6(2020):14.
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