CASIA OpenIR
In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT
Huang, Wenhui1,2; Wang, Kun2; An, Yu2; Meng, Hui2; Gao, Yuan2; Xiong, Zhiyuan1,4; Yan, Hao5; Wang, Qian6; Cai, Xuekang7; Yang, Xin2; Zhang, Bin1; Chen, Qiuying1; Yang, Xing7; Tian, Jie2,3; Zhang, Shuixing1
Source PublicationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN1619-7070
2019-11-08
Pages12
Corresponding AuthorYang, Xing(yangxing2017@bjmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Zhang, Shuixing(shui7515@126.com)
AbstractPurpose Accurate evaluation of hypoxia is particularly important in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The aim of this study was to propose a novel imaging strategy for quantitative three-dimensional (3D) evaluation of hypoxia in a small animal model of NPC. Methods A carbonic anhydrase IX (CAIX)-specific molecular probe (CAIX-800) was developed for imaging of hypoxia. Mouse models of subcutaneous, orthotopic, and spontaneous lymph node metastasis from NPC (5 mice per group) were established to assess the imaging strategy. A multi-modality imaging method that consisted of a hybrid combination of fluorescence molecular tomography-computed tomography (FMT-CT) and multispectral optoacoustic tomography (MSOT) was used for 3D quantitative evaluation of tumour hypoxia. Magnetic resonance imaging, histological examination, and immunohistochemical analysis were used as references for comparison and validation. Results In the early stage of NPC (2 weeks after implantation), FMT-CT enabled precise 3D localisation of the hypoxia biomarker with high sensitivity. At the advanced stage (6 weeks after implantation), MSOT allowed multispectral analysis of the biomarker and haemoglobin molecules with high resolution. The combination of high sensitivity and high resolution from FMT-CT and MSOT could not only detect hypoxia in small-sized NPCs but also visualise the heterogeneity of hypoxia in 3D. Conclusions Integration of FMT-CT and MSOT could allow comprehensive and quantifiable evaluation of hypoxia in NPC. These findings may potentially benefit patients with NPC undergoing radiotherapy in the future.
KeywordNasopharyngeal carcinoma Tumour hypoxia Fluorescence molecular tomography Multispectral optoacoustic tomography Carbonic anhydrase IX
DOI10.1007/s00259-019-04526-x
WOS KeywordCARBONIC-ANHYDRASE-IX ; FLUORESCENCE MOLECULAR TOMOGRAPHY ; COMBINING ANATOMY ; CELL CARCINOMA ; EXPRESSION ; HEAD ; CANCER ; MODEL ; PET ; CARBONIC-ANHYDRASE-9
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2015CB755500] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571664] ; National Natural Science Foundation of China[81871323] ; National Natural Science Foundation of China[81801665] ; National Natural Science Foundation of China[21877004] ; National Thousand Young Talents Program of China ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-059] ; Chinese Academy of Sciences[YJKYYQ20180048] ; National Natural Science Foundation of Guangdong Province[2018B030311024] ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission Grant[201707010328] ; China Postdoctoral Science Foundation[2016 M600145] ; Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities ; Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2015CB755500] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571664] ; National Natural Science Foundation of China[81871323] ; National Natural Science Foundation of China[81801665] ; National Natural Science Foundation of China[21877004] ; National Thousand Young Talents Program of China ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-059] ; Chinese Academy of Sciences[YJKYYQ20180048] ; National Natural Science Foundation of Guangdong Province[2018B030311024] ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission Grant[201707010328] ; China Postdoctoral Science Foundation[2016 M600145] ; Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; National Thousand Young Talents Program of China ; Chinese Academy of Sciences ; National Natural Science Foundation of Guangdong Province ; Scientific Research General Project of Guangzhou Science Technology and Innovation Commission Grant ; China Postdoctoral Science Foundation ; Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000495208500003
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/28901
Collection中国科学院自动化研究所
Corresponding AuthorYang, Xing; Tian, Jie; Zhang, Shuixing
Affiliation1.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, 163 Huangpu West Rd, Guangzhou 510632, Guangdong, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Mol Imaging, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
4.Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia
5.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Dept Diagnost Imaging, Natl Canc Ctr, Canc Hosp, Beijing 100021, Peoples R China
7.Peking Univ, Dept Nucl Med, Hosp 1, 8 Xishiku Rd, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Huang, Wenhui,Wang, Kun,An, Yu,et al. In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2019:12.
APA Huang, Wenhui.,Wang, Kun.,An, Yu.,Meng, Hui.,Gao, Yuan.,...&Zhang, Shuixing.(2019).In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,12.
MLA Huang, Wenhui,et al."In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019):12.
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