| A neural circuit for comorbid depressive symptoms in chronic pain | |
Zhou, Wenjie1; Jin, Yan1; Meng, Qian1; Zhu, Xia1; Bai, Tongjian2,3; Tian, Yanghua2,3; Mao, Yu1,2,3; Wang, Likui2,3; Xie, Wen4; Zhong, Hui4; Zhang, Na5,6; Luo, Min-Hua7; Tao, Wenjuan1; Wang, Haitao1 ; Li, Jie1; Li, Juan1; Qiu, Ben-Sheng1; Zhou, Jiang-Ning1; Li, Xiangyao8; Xu, Han8; Wang, Kai2,3; Zhang, Xiaochu1; Liu, Yong9; Richter-Levin, Gal10; Xu, Lin5,6; Zhang, Zhi1
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| 发表期刊 | NATURE NEUROSCIENCE
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| ISSN | 1097-6256 |
| 2019-10-01 | |
| 卷号 | 22期号:10页码:1649-+ |
| 通讯作者 | Zhang, Zhi(zhizhang@ustc.edu.cn) |
| 摘要 | Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeA neurons project directly to the lateral habenula, an area known involved in depression. Inhibition of the 5-HTDRN -> SOMCeA pathway produced depression-like behavior in a male mouse model of chronic pain. Activation of this pathway using pharmacological or optogenetic approaches reduced depression-like behavior in these mice. Human functional magnetic resonance imaging data showed that compared to healthy controls, functional connectivity between the CeA-containing centromedial amygdala and the DRN was reduced in patients with CDS but not in patients in chronic pain without depression. These findings indicate that a novel 5-HTDRN -> SOMCeA -> lateral habenula pathway may mediate at least some aspects of CDS. |
| DOI | 10.1038/s41593-019-0468-2 |
| 关键词[WOS] | PREFRONTAL CORTEX ; IN-VIVO ; AMYGDALA ; HABENULA ; MECHANISMS ; EXPERIENCE ; DISORDER ; NEURONS ; ANXIETY ; STRESS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31600851] ; National Natural Science Foundation of China[81600964] ; National Natural Science Foundation of China[81870877] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[91849119] ; National Key Research and Development Program of China[2016YFC1305900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02010000] ; National Natural Science Foundation of China[31600851] ; National Natural Science Foundation of China[81600964] ; National Natural Science Foundation of China[81870877] ; National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[91849119] ; National Key Research and Development Program of China[2016YFC1305900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02010000] |
| 项目资助者 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000493396200015 |
| 出版者 | NATURE PUBLISHING GROUP |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/28905 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Zhang, Zhi |
| 作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Brain Funct & Dis, Hefei, Anhui, Peoples R China 2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Dept Anesthesiol, Hefei, Anhui, Peoples R China 3.Anhui Med Univ, Affiliated Hosp 1, Dept Pain Management, Hefei, Anhui, Peoples R China 4.Anhui Mental Hlth Ctr, Dept Psychol, Hefei, Anhui, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming, Yunnan, Peoples R China 7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 8.Zhejiang Univ, Key Lab Neurobiol Zhejiang Prov, Dept Neurobiol,Sch Med, Key Lab Med Neurobiol,Minist Hlth China, Hangzhou, Zhejiang, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 10.Univ Haifa, Sagol Dept Neurobiol, Haifa, Israel |
| 推荐引用方式 GB/T 7714 | Zhou, Wenjie,Jin, Yan,Meng, Qian,et al. A neural circuit for comorbid depressive symptoms in chronic pain[J]. NATURE NEUROSCIENCE,2019,22(10):1649-+. |
| APA | Zhou, Wenjie.,Jin, Yan.,Meng, Qian.,Zhu, Xia.,Bai, Tongjian.,...&Zhang, Zhi.(2019).A neural circuit for comorbid depressive symptoms in chronic pain.NATURE NEUROSCIENCE,22(10),1649-+. |
| MLA | Zhou, Wenjie,et al."A neural circuit for comorbid depressive symptoms in chronic pain".NATURE NEUROSCIENCE 22.10(2019):1649-+. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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