CASIA OpenIR
Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients
Lin, Yuan1,2; Li, Lin-Lin3; Nie, Wei1; Liu, Xiaolei4; Adler, Avital2; Xiao, Chi3; Lu, Fujian1; Wang, Liping4; Han, Hua3; Wang, Xianhua1; Gan, Wen-Biao2; Cheng, Heping1
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
2019-11-21
Volume10Pages:13
Corresponding AuthorGan, Wen-Biao(Wenbiao.Gan@nyulangone.org) ; Cheng, Heping(chengp@pku.edu.cn)
AbstractMitochondrial calcium ([Ca2+](mito)) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+](mito) dynamics in vivo and its regulation by brain activity are largely unknown. By performing twophoton Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+](mito) transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+](cyto)) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+](cyto) transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+](mito)-to[Ca2+] cyto coupling affords an important mechanism whereby [Ca2+](mito) decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing.
DOI10.1038/s41467-019-13142-0
WOS KeywordPROTEIN-KINASE-II ; ESSENTIAL COMPONENT ; DENDRITIC SPINES ; MOTOR CORTEX ; CALCIUM ; DYSFUNCTION ; FREQUENCY ; DYNAMICS ; DISEASE ; ER
Indexed BySCI
Language英语
Funding ProjectNational Key Basic Research Program of China[2017YFA0504000] ; National Key Basic Research Program of China[2016YFA0500403] ; National Science Foundation of China[31670039] ; National Science Foundation of China[31970058] ; National Science Foundation of China[8182780030] ; National Science Foundation of China[31821091] ; NIH[5R01NS087198] ; NIH[5R01NS047325] ; NIH[1R21AG061751] ; National Key Basic Research Program of China[2017YFA0504000] ; National Key Basic Research Program of China[2016YFA0500403] ; National Science Foundation of China[31670039] ; National Science Foundation of China[31970058] ; National Science Foundation of China[8182780030] ; National Science Foundation of China[31821091] ; NIH[5R01NS087198] ; NIH[5R01NS047325] ; NIH[1R21AG061751]
Funding OrganizationNational Key Basic Research Program of China ; National Science Foundation of China ; NIH
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000497699100010
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/29344
Collection中国科学院自动化研究所
Corresponding AuthorGan, Wen-Biao; Cheng, Heping
Affiliation1.Peking Univ, Beijing Key Lab Cardiometab Mol Med, Peking Tsinghua Ctr Life Sci, State Key Lab Membrane Biol,Inst Mol Med, Beijing 100871, Peoples R China
2.NYU, Sch Med, Skirball Inst Biomol Med,Neurosci Inst, Dept Neurosci & Physiol,Dept Anesthesiol, New York, NY 10016 USA
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen 518055, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Lin, Yuan,Li, Lin-Lin,Nie, Wei,et al. Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients[J]. NATURE COMMUNICATIONS,2019,10:13.
APA Lin, Yuan.,Li, Lin-Lin.,Nie, Wei.,Liu, Xiaolei.,Adler, Avital.,...&Cheng, Heping.(2019).Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients.NATURE COMMUNICATIONS,10,13.
MLA Lin, Yuan,et al."Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients".NATURE COMMUNICATIONS 10(2019):13.
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