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Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients
Lin, Yuan1,2; Li, Lin-Lin3; Nie, Wei1; Liu, Xiaolei4; Adler, Avital2; Xiao, Chi3; Lu, Fujian1; Wang, Liping4; Han, Hua3; Wang, Xianhua1; Gan, Wen-Biao2; Cheng, Heping1
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
2019-11-21
卷号10页码:13
通讯作者Gan, Wen-Biao(Wenbiao.Gan@nyulangone.org) ; Cheng, Heping(chengp@pku.edu.cn)
摘要Mitochondrial calcium ([Ca2+](mito)) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+](mito) dynamics in vivo and its regulation by brain activity are largely unknown. By performing twophoton Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+](mito) transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+](cyto)) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+](cyto) transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+](mito)-to[Ca2+] cyto coupling affords an important mechanism whereby [Ca2+](mito) decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing.
DOI10.1038/s41467-019-13142-0
关键词[WOS]PROTEIN-KINASE-II ; ESSENTIAL COMPONENT ; DENDRITIC SPINES ; MOTOR CORTEX ; CALCIUM ; DYSFUNCTION ; FREQUENCY ; DYNAMICS ; DISEASE ; ER
收录类别SCI
语种英语
资助项目National Key Basic Research Program of China[2017YFA0504000] ; National Key Basic Research Program of China[2016YFA0500403] ; National Science Foundation of China[31670039] ; National Science Foundation of China[31970058] ; National Science Foundation of China[8182780030] ; National Science Foundation of China[31821091] ; NIH[5R01NS087198] ; NIH[5R01NS047325] ; NIH[1R21AG061751] ; National Key Basic Research Program of China[2017YFA0504000] ; National Key Basic Research Program of China[2016YFA0500403] ; National Science Foundation of China[31670039] ; National Science Foundation of China[31970058] ; National Science Foundation of China[8182780030] ; National Science Foundation of China[31821091] ; NIH[5R01NS087198] ; NIH[5R01NS047325] ; NIH[1R21AG061751]
项目资助者National Key Basic Research Program of China ; National Science Foundation of China ; NIH
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000497699100010
出版者NATURE PUBLISHING GROUP
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/29344
专题类脑智能研究中心_微观重建与智能分析
中国科学院自动化研究所
通讯作者Gan, Wen-Biao; Cheng, Heping
作者单位1.Peking Univ, Beijing Key Lab Cardiometab Mol Med, Peking Tsinghua Ctr Life Sci, State Key Lab Membrane Biol,Inst Mol Med, Beijing 100871, Peoples R China
2.NYU, Sch Med, Skirball Inst Biomol Med,Neurosci Inst, Dept Neurosci & Physiol,Dept Anesthesiol, New York, NY 10016 USA
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen 518055, Guangdong, Peoples R China
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GB/T 7714
Lin, Yuan,Li, Lin-Lin,Nie, Wei,et al. Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients[J]. NATURE COMMUNICATIONS,2019,10:13.
APA Lin, Yuan.,Li, Lin-Lin.,Nie, Wei.,Liu, Xiaolei.,Adler, Avital.,...&Cheng, Heping.(2019).Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients.NATURE COMMUNICATIONS,10,13.
MLA Lin, Yuan,et al."Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients".NATURE COMMUNICATIONS 10(2019):13.
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