CASIA OpenIR  > 中国科学院分子影像重点实验室
First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows
Hu, Zhenhua1,2; Fang, Cheng3; Li, Bo3; Zhang, Zeyu1,4; Cao, Caiguang1,2; Cai, Meishan1,2; Su, Song3; Sun, Xingwang3; Shi, Xiaojing1,2; Li, Cong1,2; Zhou, Tiejun3; Zhang, Yuanxue3; Chi, Chongwei1; He, Pan3; Xia, Xianming3; Chen, Yue3; Gambhir, Sanjiv Sam5,6; Cheng, Zhen5,6; Tian, Jie1,2,4,7
Source PublicationNATURE BIOMEDICAL ENGINEERING
ISSN2157-846X
2019-12-23
Volume4Issue:3Pages:16
Corresponding AuthorGambhir, Sanjiv Sam(sgambhir@stanford.edu) ; Cheng, Zhen(zcheng@stanford.edu) ; Tian, Jie(tian@ieee.org)
AbstractThe second near-infrared wavelength window (NIR-II, 1,000-1,700 nm) enables fluorescence imaging of tissue with enhanced contrast at depths of millimetres and at micrometre-scale resolution. However, the lack of clinically viable NIR-II equipment has hindered the clinical translation of NIR-II imaging. Here, we describe an optical-imaging instrument that integrates a visible multispectral imaging system with the detection of NIR-II and NIR-I (700-900 nm in wavelength) fluorescence (by using the dye indocyanine green) for aiding the fluorescence-guided surgical resection of primary and metastatic liver tumours in 23 patients. We found that, compared with NIR-I imaging, intraoperative NIR-II imaging provided a higher tumour-detection sensitivity (100% versus 90.6%; with 95% confidence intervals of 89.1%-100% and 75.0%-98.0%, respectively), a higher tumour-to-normal-liver-tissue signal ratio (5.33 versus 1.45) and an enhanced tumour-detection rate (56.41% versus 46.15%). We infer that combining the NIR-I/II spectral windows and suitable fluorescence probes might improve image-guided surgery in the clinic. An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.
DOI10.1038/s41551-019-0494-0
WOS KeywordINDOCYANINE GREEN ; II FLUORESCENCE ; FLUOROPHORES ; CANCER
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[81227901] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[81227901] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
WOS IDWOS:000507725800001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:207[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/29526
Collection中国科学院分子影像重点实验室
Corresponding AuthorGambhir, Sanjiv Sam; Cheng, Zhen; Tian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Managem, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Southwest Med Univ, Dept Hepatobiliary Surg Pathol & Nucl Med, Affiliated Hosp, Luzhou, Peoples R China
4.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Peoples R China
5.Stanford Univ, Mol Imaging Program Stanford, Bio X Program, Stanford, CA 94305 USA
6.Stanford Univ, Dept Radiol, Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA
7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Zhenhua,Fang, Cheng,Li, Bo,et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows[J]. NATURE BIOMEDICAL ENGINEERING,2019,4(3):16.
APA Hu, Zhenhua.,Fang, Cheng.,Li, Bo.,Zhang, Zeyu.,Cao, Caiguang.,...&Tian, Jie.(2019).First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows.NATURE BIOMEDICAL ENGINEERING,4(3),16.
MLA Hu, Zhenhua,et al."First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows".NATURE BIOMEDICAL ENGINEERING 4.3(2019):16.
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