Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging

	Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging
	Li, Yonghui 1,2; Du, Hanjian ; Xie, Bing 4; Wu, Nan 3; Wang, Jian 4; Wu, Guocai 3; Feng, Hua 3; Jiang, Tianzi2,5
发表期刊	PLOS ONE
	2010-12-21
卷号	5 期号:12
文章类型	Article
摘要	Although there is increasing evidence suggesting that there may be subtle abnormalities in idiopathic generalized epilepsy (IGE) patients using modern neuroimaging techniques, most of these previous studies focused on the brain grey matter, leaving the underlying white matter abnormalities in IGE largely unknown, which baffles the treatment as well as the understanding of IGE. In this work, we adopted multiple methods from different levels based on diffusion tensor imaging (DTI) to analyze the white matter abnormalities in 14 young male IGE patients with generalized tonic-clonic seizures (GTCS) only, comparing with 29 age-matched male healthy controls. First, we performed a voxel-based analysis (VBA) of the fractional anisotropy (FA) images derived from DTI. Second, we used a tract-based spatial statistics (TBSS) method to explore the alterations within the white matter skeleton of the patients. Third, we adopted region-of-interest (ROI) analyses based on the findings of VBA and TBSS to further confirm abnormal brain regions in the patients. At last, considering the convergent evidences we found by VBA, TBSS and ROI analyses, a subsequent probabilistic fiber tractography study was performed to investigate the abnormal white matter connectivity in the patients. Significantly decreased FA values were consistently observed in the cerebellum of patients, providing fresh evidence and new clues for the important role of cerebellum in IGE with GTCS.
WOS标题词	Science & Technology
关键词[WOS]	DT-MRI DATA ; HUMAN THALAMUS ; WHITE-MATTER ; HUMAN BRAIN ; TRACTOGRAPHY ; CONNECTIVITY ; CORTEX ; GANGLIOGLIOMA ; STIMULATION ; PATTERNS
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000285576900023
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3108
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Natl Res Ctr Intelligent Comp Syst, Inst Comp Technol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China 3.Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China 4.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Li, Yonghui,Du, Hanjian,Xie, Bing,et al. Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging[J]. PLOS ONE,2010,5(12).
APA	Li, Yonghui.,Du, Hanjian.,Xie, Bing.,Wu, Nan.,Wang, Jian.,...&Jiang, Tianzi.(2010).Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging.PLOS ONE,5(12).
MLA	Li, Yonghui,et al."Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging".PLOS ONE 5.12(2010).