Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls

	Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
	Wang, Fei 1,2,3; Jiang, Tianzi2 ; Sun, Zhiguo 4; Teng, Siew-leng 5; Luo, Xingguang 3; Zhu, Zhongjun 1; Zang, Yufeng 2; Zhang, Handi 1; Yue, Weihua 1; Qu, Mei 1; Lu, Tianlan 1; Hong, Nan 4; Huang, Haiyan 5; Blumberg, Hilary P.3; Zhang, Dai1
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE
	2009-05-01
卷号	34 期号:3 页码:181-186
文章类型	Article
摘要	Background: Neuregulin1 (NRG1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. The cingulum bundle is a white matter structure implicated in schizophrenia. Its anterior component is especially implicated, as it provides reciprocal connections between brain regions with prominent involvement in the disorder. Abnormalities in the structural integrity of the anterior cingulum in patients with schizophrenia have been reported previously. The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia. Methods: We studied 31 men with schizophrenia and 36 healthy men using diffusion tensor imaging to investigate the association between fractional anisotropy in the anterior cingulum and a single-nucleotide polymorphism (SNP8NRG221533: rs35753505) of NRG1. Results: Consistent with previous reports, fractional anisotropy was significantly reduced in the anterior cingulum in the schizophrenia group. Moreover, the results revealed a significant group (schizophrenia, control) by genotype (C/C, T carriers, including CT and TT) interaction between genetic variation in NRG1 and diagnosis of schizophrenia, such that the patients with the T allele for SNP8NRG221533 had significantly decreased anterior cingulum fractional anisotropy compared with patients homozygous for the C allele and healthy controls who were T carriers. Limitations: Limitations of our study included the small sample size of the TT subgroup and our use of only fractional anisotropy as an index of myelin integrity. In addition, the use of diffusion tensor imaging acquisition methods limited our ability to study other brain regions that may be involved in schizophrenia. Conclusion: Our results suggest that NRG1 variation may play a role in the pathophysiology of anterior cingulum abnormalities in patients with schizophrenia.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DIFFUSION TENSOR ; NRG1 GENE ; PREFRONTAL CORTEX ; IN-VIVO ; ASSOCIATION ; POPULATION ; SUSCEPTIBILITY ; ABNORMALITIES ; SUPPORT ; MYELIN
收录类别	SCI ; SSCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Neurosciences ; Psychiatry
WOS记录号	WOS:000265540400003
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3128
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA 4.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100083, Peoples R China 5.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Wang, Fei,Jiang, Tianzi,Sun, Zhiguo,et al. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2009,34(3):181-186.
APA	Wang, Fei.,Jiang, Tianzi.,Sun, Zhiguo.,Teng, Siew-leng.,Luo, Xingguang.,...&Zhang, Dai.(2009).Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,34(3),181-186.
MLA	Wang, Fei,et al."Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 34.3(2009):181-186.