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Recombination rates of human microRNA
Zhao, Huizhi1,2,3; Wang, Dong3,4; Liu, Bing1,2; Jiang, Xingpeng1,2; Zhang, Jing1,2; Fan, Ming1,2; Fan, Zhengjie1,2; Chen, Ying1,2; Song, Sonya Wei1,2; Gao, Wei3,4; Jiang, Tianzi1,2; Cui, Qinghua3,4
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-02-13
Volume379Issue:3Pages:702-705
SubtypeArticle
AbstractThe fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help ill understanding the function, evolution, and disease-related roles of microRNAs. (C) 2008 Elsevier Inc. All rights reserved.
KeywordMicrornas Recombination Rate Tissue Specificity Disease Microrna Expression Level
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordHUMAN GENOME ; GENETIC ROBUSTNESS ; HUMAN TISSUES ; GC CONTENT ; EXPRESSION ; EVOLUTION ; PROFILES ; CANCER ; BIAS
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000263258100011
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3132
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Med Informat, Beijing 100083, Peoples R China
4.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100191, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Huizhi,Wang, Dong,Liu, Bing,et al. Recombination rates of human microRNA[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(3):702-705.
APA Zhao, Huizhi.,Wang, Dong.,Liu, Bing.,Jiang, Xingpeng.,Zhang, Jing.,...&Cui, Qinghua.(2009).Recombination rates of human microRNA.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(3),702-705.
MLA Zhao, Huizhi,et al."Recombination rates of human microRNA".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.3(2009):702-705.
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