Recombination rates of human microRNA

	Recombination rates of human microRNA
	Zhao, Huizhi 1,2,3; Wang, Dong 3,4; Liu, Bing1,2 ; Jiang, Xingpeng 1,2; Zhang, Jing 1,2; Fan, Ming 1,2; Fan, Zhengjie 1,2; Chen, Ying 1,2; Song, Sonya Wei 1,2; Gao, Wei 3,4; Jiang, Tianzi1,2 ; Cui, Qinghua 3,4
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2009-02-13
卷号	379 期号:3 页码:702-705
文章类型	Article
摘要	The fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help ill understanding the function, evolution, and disease-related roles of microRNAs. (C) 2008 Elsevier Inc. All rights reserved.
关键词	Micrornas Recombination Rate Tissue Specificity Disease Microrna Expression Level
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	HUMAN GENOME ; GENETIC ROBUSTNESS ; HUMAN TISSUES ; GC CONTENT ; EXPRESSION ; EVOLUTION ; PROFILES ; CANCER ; BIAS
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000263258100011
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3132
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Peking Univ, Hlth Sci Ctr, Dept Med Informat, Beijing 100083, Peoples R China 4.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100191, Peoples R China
第一作者单位	中国科学院自动化研究所; 模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhao, Huizhi,Wang, Dong,Liu, Bing,et al. Recombination rates of human microRNA[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(3):702-705.
APA	Zhao, Huizhi.,Wang, Dong.,Liu, Bing.,Jiang, Xingpeng.,Zhang, Jing.,...&Cui, Qinghua.(2009).Recombination rates of human microRNA.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(3),702-705.
MLA	Zhao, Huizhi,et al."Recombination rates of human microRNA".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.3(2009):702-705.