Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study

	Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study
	Zhu, Ye 2; Liu, Xuan 1; Wang, Huiling 1; Jiang, Tianzi2 ; Fang, Yue 1; Hu, Hanbin 2; Wang, Gaohua 1; Wang, Xiaoping 1; Liu, Zhongchun 1; Zhang, Kai 1
发表期刊	NEUROSCIENCE LETTERS
	2010-07-12
卷号	478 期号:3 页码:136-140
文章类型	Article
摘要	Cognitive impairments are considered as a core feature of schizophrenia and have been reported in associated with dysfunction of the prefrontal cortex (PFC). The Tower of London (TOL) task is a widely used neuropsychological test to assess the planning ability and the PFC function. In the present study. we examined functional changes in the PFC of 40 first-episode schizophrenia patients and 40 age- and gender-matched healthy controls by means of multi-channel Near-infrared spectroscopy (MRS) during performance of the TOL task. NIRS is a noninvasive optical method that can measure relative changes in oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin in cortical tissue. Compared to the healthy controls, schizophrenia patients exhibited a significant decreased activation in the left PFC and poorer TOL performance. The results confirm the functional deficits of the PFC and impaired planning ability in first-episode schizophrenia patients and suggest that NIRS may be a useful clinical tool for evaluating PFC activation in psychiatric disorders. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Schizophrenia Multi-channel Near-infrared Spectroscopy (Nirs) Tower Of London (Tol) Prefrontal Cortex (Pfc)
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DYSFUNCTION ; TASK
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000279525700006
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3134
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Ye,Liu, Xuan,Wang, Huiling,et al. Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study[J]. NEUROSCIENCE LETTERS,2010,478(3):136-140.
APA	Zhu, Ye.,Liu, Xuan.,Wang, Huiling.,Jiang, Tianzi.,Fang, Yue.,...&Zhang, Kai.(2010).Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study.NEUROSCIENCE LETTERS,478(3),136-140.
MLA	Zhu, Ye,et al."Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study".NEUROSCIENCE LETTERS 478.3(2010):136-140.