CASIA OpenIR  > 脑网络组研究中心
Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study
Zhu, Ye2; Liu, Xuan1; Wang, Huiling1; Jiang, Tianzi2; Fang, Yue1; Hu, Hanbin2; Wang, Gaohua1; Wang, Xiaoping1; Liu, Zhongchun1; Zhang, Kai1
Source PublicationNEUROSCIENCE LETTERS
2010-07-12
Volume478Issue:3Pages:136-140
SubtypeArticle
AbstractCognitive impairments are considered as a core feature of schizophrenia and have been reported in associated with dysfunction of the prefrontal cortex (PFC). The Tower of London (TOL) task is a widely used neuropsychological test to assess the planning ability and the PFC function. In the present study. we examined functional changes in the PFC of 40 first-episode schizophrenia patients and 40 age- and gender-matched healthy controls by means of multi-channel Near-infrared spectroscopy (MRS) during performance of the TOL task. NIRS is a noninvasive optical method that can measure relative changes in oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin in cortical tissue. Compared to the healthy controls, schizophrenia patients exhibited a significant decreased activation in the left PFC and poorer TOL performance. The results confirm the functional deficits of the PFC and impaired planning ability in first-episode schizophrenia patients and suggest that NIRS may be a useful clinical tool for evaluating PFC activation in psychiatric disorders. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordSchizophrenia Multi-channel Near-infrared Spectroscopy (Nirs) Tower Of London (Tol) Prefrontal Cortex (Pfc)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDYSFUNCTION ; TASK
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000279525700006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3134
Collection脑网络组研究中心
Affiliation1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China
2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Ye,Liu, Xuan,Wang, Huiling,et al. Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study[J]. NEUROSCIENCE LETTERS,2010,478(3):136-140.
APA Zhu, Ye.,Liu, Xuan.,Wang, Huiling.,Jiang, Tianzi.,Fang, Yue.,...&Zhang, Kai.(2010).Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study.NEUROSCIENCE LETTERS,478(3),136-140.
MLA Zhu, Ye,et al."Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study".NEUROSCIENCE LETTERS 478.3(2010):136-140.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, Ye]'s Articles
[Liu, Xuan]'s Articles
[Wang, Huiling]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, Ye]'s Articles
[Liu, Xuan]'s Articles
[Wang, Huiling]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, Ye]'s Articles
[Liu, Xuan]'s Articles
[Wang, Huiling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.