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Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex
Hao, Yihui2; Yan, Qiang1; Liu, Haihong2; Xu, Lin2,3; Xue, Zhimin2; Song, Xueqin4; Kaneko, Yoshio5; Jiang, Tianzi6; Liu, Zhening2; Shan, Baoci1
Source PublicationSCHIZOPHRENIA RESEARCH
2009-10-01
Volume114Issue:1-3Pages:128-135
SubtypeArticle
AbstractHealthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophrenia. However, it remains unclear whether schizophrenia patients and their healthy siblings share a specific pattern of disruption of WM integrity that may be related to the disease risk. The objective of this study is to determine whether a specific brain regional pattern of disruption of WM integrity is shared by schizophrenia patients and their healthy siblings. We investigated brain white matter abnormalities by voxel-based analysis of white matter FA data acquired from diffusion tensor imaging in 34 pairs of schizophrenia patients and their healthy siblings, as well as in 32 healthy controls. Both schizophrenia patients and their healthy siblings showed reduced white matter FA in the left prefrontal cortex and the hippocampus in comparison to healthy controls, without significant difference between patients and siblings. In marked contrast, only schizophrenia patients exhibited reduced white matter FA in the left anterior cingulate cortex in comparison to both siblings and controls, without significant difference between siblings and controls. Thus, schizophrenia patients and their healthy siblings share disruption of WM integrity in the left prefrontal cortex and the hippocampus that may be related to higher risk of healthy siblings to develop schizophrenia, which may be eventually attributed to additional disruption of WM integrity in the left anterior cingulate cortex. (C) 2009 Elsevier B.V. All rights reserved.
KeywordSchizophrenia Healthy Siblings Diffusion Tensor Imaging Fractional Anisotropy
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS Keyword1ST-EPISODE SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES ; COGNITIVE CONTROL ; GENETIC RISK ; STROOP TASK ; DIFFUSION ; BRAIN ; MRI ; ABNORMALITIES ; CONNECTIVITY
Indexed BySCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000270758700018
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3137
Collection脑网络组研究
Affiliation1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal, Beijing 100049, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Peoples R China
4.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China
5.Yale Univ, Sch Med, New Haven, CT USA
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Hao, Yihui,Yan, Qiang,Liu, Haihong,et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex[J]. SCHIZOPHRENIA RESEARCH,2009,114(1-3):128-135.
APA Hao, Yihui.,Yan, Qiang.,Liu, Haihong.,Xu, Lin.,Xue, Zhimin.,...&Shan, Baoci.(2009).Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex.SCHIZOPHRENIA RESEARCH,114(1-3),128-135.
MLA Hao, Yihui,et al."Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex".SCHIZOPHRENIA RESEARCH 114.1-3(2009):128-135.
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