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Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders
Zhou, Yuan1,2; Wang, Kun1; Liu, Yong1; Song, Ming1; Song, Sonya W.1; Jiang, Tianzi1,3
Source PublicationCOGNITIVE NEURODYNAMICS
2010
Volume4Issue:4Pages:275-294
SubtypeReview
AbstractAs functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.
KeywordResting-state Fmri Low Frequency Fluctuation Functional Connectivity Alzheimer's Disease Schizophrenia
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SMALL-WORLD NETWORKS ; LOW-FREQUENCY FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; BOLD SIGNAL FLUCTUATIONS ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; CEREBRAL-CORTEX ; ANATOMICAL CONNECTIVITY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000284241800002
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3139
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing 100101, Peoples R China
3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Wang, Kun,Liu, Yong,et al. Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders[J]. COGNITIVE NEURODYNAMICS,2010,4(4):275-294.
APA Zhou, Yuan,Wang, Kun,Liu, Yong,Song, Ming,Song, Sonya W.,&Jiang, Tianzi.(2010).Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders.COGNITIVE NEURODYNAMICS,4(4),275-294.
MLA Zhou, Yuan,et al."Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders".COGNITIVE NEURODYNAMICS 4.4(2010):275-294.
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