Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

	Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders
	Zhou, Yuan 1,2; Wang, Kun 1; Liu, Yong1 ; Song, Ming1 ; Song, Sonya W.1; Jiang, Tianzi1,3
发表期刊	COGNITIVE NEURODYNAMICS
	2010
卷号	4 期号:4 页码:275-294
文章类型	Review
摘要	As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.
关键词	Resting-state Fmri Low Frequency Fluctuation Functional Connectivity Alzheimer's Disease Schizophrenia
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SMALL-WORLD NETWORKS ; LOW-FREQUENCY FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; BOLD SIGNAL FLUCTUATIONS ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; CEREBRAL-CORTEX ; ANATOMICAL CONNECTIVITY
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000284241800002
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3139
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing 100101, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhou, Yuan,Wang, Kun,Liu, Yong,et al. Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders[J]. COGNITIVE NEURODYNAMICS,2010,4(4):275-294.
APA	Zhou, Yuan,Wang, Kun,Liu, Yong,Song, Ming,Song, Sonya W.,&Jiang, Tianzi.(2010).Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders.COGNITIVE NEURODYNAMICS,4(4),275-294.
MLA	Zhou, Yuan,et al."Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders".COGNITIVE NEURODYNAMICS 4.4(2010):275-294.