| Thick Visual Cortex in the Early Blind | |
Jiang, Jiefeng1; Zhu, Wanlin1,2; Shi, Feng1; Liu, Yong1 ; Li, Jun1; Qin, Wen3; Li, Kuncheng3; Yu, Chunshui3; Jiang, Tianzi1
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| 发表期刊 | JOURNAL OF NEUROSCIENCE
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| 2009-02-18 | |
| 卷号 | 29期号:7页码:2205-2211 |
| 文章类型 | Article |
| 摘要 | We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing the thickness of the visual cortex in humans with early- and late-onset blindness. The bilateral visual cortices of the early blind were significantly thicker than those of the late blind and the sighted controls, but the latter two groups did not differ significantly. This suggests reduced "pruning" of synapses in the visual cortex, which may be due to a lack of visual experience during a critical developmental period. These findings support the hypothesis that sensory experience is necessary for an appropriate regression and remodeling of neuronal processes and that synaptic regression might be a major determinant of macroscopic anatomical features like cortical thickness. |
| 关键词 | Cortical Thickness Blind Plasticity Visual Deprivation Magnetic Resonance Imaging Development |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | CROSS-MODAL PLASTICITY ; CORTICAL THICKNESS ; RETINAL INPUT ; WHITE-MATTER ; POSTNATAL-DEVELOPMENT ; CONGENITALLY BLIND ; HUMAN BRAIN ; DEPRIVATION ; CONNECTIVITY ; ORGANIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000263558900024 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/3141 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China |
| 第一作者单位 | 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Jiang, Jiefeng,Zhu, Wanlin,Shi, Feng,et al. Thick Visual Cortex in the Early Blind[J]. JOURNAL OF NEUROSCIENCE,2009,29(7):2205-2211. |
| APA | Jiang, Jiefeng.,Zhu, Wanlin.,Shi, Feng.,Liu, Yong.,Li, Jun.,...&Jiang, Tianzi.(2009).Thick Visual Cortex in the Early Blind.JOURNAL OF NEUROSCIENCE,29(7),2205-2211. |
| MLA | Jiang, Jiefeng,et al."Thick Visual Cortex in the Early Blind".JOURNAL OF NEUROSCIENCE 29.7(2009):2205-2211. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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