| Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography | |
Li, Jiajia1; Liu, Yong1 ; Qin, Wen2; Jiang, Jiefeng1; Qiu, Zhaoxiong3; Xu, Jiacheng3; Yu, Chunshui2; Jiang, Tianzi1,4,5; Jiang T
| |
| 发表期刊 | CEREBRAL CORTEX
 |
| 2013-03-01 | |
| 卷号 | 23期号:3页码:542-551 |
| 文章类型 | Article |
| 摘要 | Studying blindness with various onset ages may elucidate the ways that unimodal sensory deprivation at different periods of development shape the human brain. In order to determine the effect of the onset age on brain anatomical networks, we extended a previous study of 17 early blind (EB) subjects with an additional 97 subjects with various onset ages. We constructed binary anatomical networks of these subjects and sighted controls (SC) using diffusion tensor tractography and calculated the topological properties of the network. Based on onset age, the subjects were divided into congenitally blind (CB), EB, adolescent-blind (AB), and late-blind (LB) subgroups. The LB subjects demonstrated a greater connectivity density and a higher global efficiency, similar to the SC. The CB and EB subgroups showed large group differences from the other groups in their topological networks, specifically, a reduced connectivity density and a decreased global efficiency compared with the SC, especially in the frontal and occipital cortices. Additionally, significant correlations were found between age of onset and the topological properties of the anatomical network in the blind. Our results suggest that visual experience during an early period of development is critical for establishing an intact efficient anatomical network in the human brain. |
| 关键词 | Age Of Onset Anatomical Network Blindness Diffusion Tensor Imaging Tractography |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | SMALL-WORLD NETWORKS ; CROSS-MODAL PLASTICITY ; VISUAL-CORTEX ; CONGENITALLY BLIND ; WHITE-MATTER ; FUNCTIONAL CONNECTIVITY ; MODULAR ORGANIZATION ; STRUCTURAL NETWORKS ; SPATIAL NAVIGATION ; CORTICAL THICKNESS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000316275400005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/3146 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Jiang T |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 3.Beijing Union Univ, Special Educ Coll, Beijing 100075, Peoples R China 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 第一作者单位 | 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Jiajia,Liu, Yong,Qin, Wen,et al. Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography[J]. CEREBRAL CORTEX,2013,23(3):542-551. |
| APA | Li, Jiajia.,Liu, Yong.,Qin, Wen.,Jiang, Jiefeng.,Qiu, Zhaoxiong.,...&Jiang T.(2013).Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography.CEREBRAL CORTEX,23(3),542-551. |
| MLA | Li, Jiajia,et al."Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography".CEREBRAL CORTEX 23.3(2013):542-551. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| LiJiajia_CC_2013.pdf（8780KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论