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Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography
Li, Jiajia1; Liu, Yong1; Qin, Wen2; Jiang, Jiefeng1; Qiu, Zhaoxiong3; Xu, Jiacheng3; Yu, Chunshui2; Jiang, Tianzi1,4,5; Jiang T
Source PublicationCEREBRAL CORTEX
2013-03-01
Volume23Issue:3Pages:542-551
SubtypeArticle
AbstractStudying blindness with various onset ages may elucidate the ways that unimodal sensory deprivation at different periods of development shape the human brain. In order to determine the effect of the onset age on brain anatomical networks, we extended a previous study of 17 early blind (EB) subjects with an additional 97 subjects with various onset ages. We constructed binary anatomical networks of these subjects and sighted controls (SC) using diffusion tensor tractography and calculated the topological properties of the network. Based on onset age, the subjects were divided into congenitally blind (CB), EB, adolescent-blind (AB), and late-blind (LB) subgroups. The LB subjects demonstrated a greater connectivity density and a higher global efficiency, similar to the SC. The CB and EB subgroups showed large group differences from the other groups in their topological networks, specifically, a reduced connectivity density and a decreased global efficiency compared with the SC, especially in the frontal and occipital cortices. Additionally, significant correlations were found between age of onset and the topological properties of the anatomical network in the blind. Our results suggest that visual experience during an early period of development is critical for establishing an intact efficient anatomical network in the human brain.
KeywordAge Of Onset Anatomical Network Blindness Diffusion Tensor Imaging Tractography
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSMALL-WORLD NETWORKS ; CROSS-MODAL PLASTICITY ; VISUAL-CORTEX ; CONGENITALLY BLIND ; WHITE-MATTER ; FUNCTIONAL CONNECTIVITY ; MODULAR ORGANIZATION ; STRUCTURAL NETWORKS ; SPATIAL NAVIGATION ; CORTICAL THICKNESS
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000316275400005
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3146
Collection脑网络组研究中心
Corresponding AuthorJiang T
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
2.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
3.Beijing Union Univ, Special Educ Coll, Beijing 100075, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Jiajia,Liu, Yong,Qin, Wen,et al. Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography[J]. CEREBRAL CORTEX,2013,23(3):542-551.
APA Li, Jiajia.,Liu, Yong.,Qin, Wen.,Jiang, Jiefeng.,Qiu, Zhaoxiong.,...&Jiang T.(2013).Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography.CEREBRAL CORTEX,23(3),542-551.
MLA Li, Jiajia,et al."Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography".CEREBRAL CORTEX 23.3(2013):542-551.
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