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Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects
Wang, Junping1; Qin, Wen1; Liu, Bing2; Wang, Dawei1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1
Source PublicationNEUROIMAGE
2013-11-01
Volume81Pages:199-204
SubtypeArticle
AbstractThe oxytocin receptor gene (OXTR) rs53576A has been associated with autism spectrum disorders (ASDs). A smaller hypothalamic volume has been reported in healthy male A-allele carriers than in male GG homozygotes and in patients with ASDs than in healthy controls. These findings prompt the hypothesis that male AA homozygotes may have weaker hypothalamic functional connectivity when compared to male G-allele carriers. We calculated local functional connectivity density (FCD) using a voxel-wise data-driven approach based on resting-state functional MRI data in 270 young healthy subjects. Both the main effect of genotype and the gender-by-genotype interaction were considered. Of the whole brain, only the local FCD of the hypothalamus exhibited the main effect of genotype. Post-hoc testing revealed significantly lower local FCD in male AA homozygotes compared to male G-allele carriers although there was only a trend of significance in the gender-by-genotype interaction. We further analyzed the resting-state functional connectivity (rsFC) of the hypothalamic region that demonstrating significant genotype differences in local FCD. We found a significant gender-by-genotype interaction in rsFC between the hypothalamic region and the left dorsolateral prefrontal cortex, but no significant main effect of genotype was found. Post-hoc testing revealed that this rsFC was significantly weaker in male AA homozygotes compared to male G-allele carriers. Our findings identify gender-dependent mechanisms of OXTR rs53576 gene variation impacting the functional connectivity of the hypothalamus in healthy individuals and suggest that these mechanisms are important for understanding ASDs. (C) 2013 Elsevier Inc. All rights reserved.
KeywordOxytocin Receptor Single Nucleotide Polymorphism Autism Hypothalamus Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAUTISM SPECTRUM DISORDERS ; OXYTOCIN RECEPTOR OXTR ; VASOPRESSIN ; MRI ; THERAPEUTICS ; ASSOCIATION ; POPULATION ; BEHAVIOR ; MATTER ; MEMORY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000322934400019
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3158
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Junping,Qin, Wen,Liu, Bing,et al. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects[J]. NEUROIMAGE,2013,81:199-204.
APA Wang, Junping.,Qin, Wen.,Liu, Bing.,Wang, Dawei.,Zhang, Yunting.,...&Yu, Chunshui.(2013).Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects.NEUROIMAGE,81,199-204.
MLA Wang, Junping,et al."Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects".NEUROIMAGE 81(2013):199-204.
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