Longitudinal changes in sulcal morphology associated with late-life aging and MCI

	Longitudinal changes in sulcal morphology associated with late-life aging and MCI
	Liu, Tao 1; Sachdev, Perminder S.1,2; Lipnicki, Darren M.1; Jiang, Jiyang 1; Cui, Yue1,3 ; Kochan, Nicole A.1,2; Reppermund, Simone 1; Trollor, Julian N.1,4; Brodaty, Henry 1,5,6; Wen, Wei 1,2
发表期刊	NEUROIMAGE
	2013-07-01
卷号	74 页码:337-342
文章类型	Article
摘要	The present study investigated changes in sulcal morphology associated with late-life aging and mild cognitive impairment (MCI). Participants were 219 community-dwelling 70-90 year-olds from the Sydney Memory and Ageing Study; all had MRI scans and were classified as having normal cognition (NC) or MCI at each of waves 1 and 2, two years apart. Automated methods were used to calculate a global sulcal index (g-SI), widths of five prominent sulci, and regional cortical thickness. There were significant longitudinal declines in g-SI and increases in sulcal width among the entire sample, but the rate of change differed among cognitive subgroups. Participants with MCI at both waves (persisting MCI) showed accelerated sulcal widening, particularly for the superior frontal and superior temporal sulci. The sulcal morphology of participants who reverted from MCI to NC was more consistent with stable NC than persisting MCI. Overall cortical thickness decreased between waves similarly across the subgroups. While changes in sulcal morphology are characteristic of normal late-life aging, they are accelerated in individuals with MCI (in contrast to changes in cortical thickness). Sulcal measures also differentiate between persistent MCI and MCI that reverts to NC, and may thus help in predicting the prognosis of MCI patients. Crown Copyright (c) 2013 Published by Elsevier Inc. All rights reserved.
关键词	Cortical Sulci Magnetic Resonance Imaging Mild Cognitive Impairment Aging Sulcal Width
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; HUMAN CEREBRAL-CORTEX ; ALZHEIMERS-DISEASE ; CORTICAL THICKNESS ; BRAIN ; PATTERNS ; AGE ; VARIABILITY ; ATROPHY ; SYSTEM
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000317441300033
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3161
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ New S Wales, Sch Psychiat, Ctr Hlth Brain Ageing CHeBA, Sydney, NSW, Australia 2.Prince Wales Hosp, Inst Neuropsychiat, Randwick, NSW 2031, Australia 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100864, Peoples R China 4.Univ New S Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia 5.Prince Wales Hosp, Aged Care Psychiat, Randwick, NSW 2031, Australia 6.Univ New S Wales, Dementia Collaborat Res Ctr, Sydney, NSW, Australia
推荐引用方式 GB/T 7714	Liu, Tao,Sachdev, Perminder S.,Lipnicki, Darren M.,et al. Longitudinal changes in sulcal morphology associated with late-life aging and MCI[J]. NEUROIMAGE,2013,74:337-342.
APA	Liu, Tao.,Sachdev, Perminder S..,Lipnicki, Darren M..,Jiang, Jiyang.,Cui, Yue.,...&Wen, Wei.(2013).Longitudinal changes in sulcal morphology associated with late-life aging and MCI.NEUROIMAGE,74,337-342.
MLA	Liu, Tao,et al."Longitudinal changes in sulcal morphology associated with late-life aging and MCI".NEUROIMAGE 74(2013):337-342.