Anatomical insights into disrupted small-world networks in schizophrenia

	Anatomical insights into disrupted small-world networks in schizophrenia
	Wang, Qifeng 1; Su, Tung-Ping 2,3; Zhou, Yuan 4; Chou, Kun-Hsien 5; Chen, I-Yun 5; Jiang, Tianzi1,6,7 ; Lin, Ching-Po 5
发表期刊	NEUROIMAGE
	2012-01-16
卷号	59 期号:2 页码:1085-1093
文章类型	Article
摘要	Schizophrenia is characterized by lowered efficiency in distributed information processing, as indicated by research that identified a disrupted small-world functional network. However, whether the dysconnection manifested by the disrupted small-world functional network is reflected in underlying anatomical disruption in schizophrenia remains unresolved. This study examined the topological properties of human brain anatomical networks derived from diffusion tensor imaging in patients with schizophrenia and in healthy controls. We constructed the weighted brain anatomical network for each of 79 schizophrenia patients and for 96 age and gender matched healthy subjects using diffusion tensor tractography and calculated the topological properties of the networks using a graph theoretical method. The topological properties of the patients' anatomical networks were altered, in that global efficiency decreased but local efficiency remained unchanged. The deleterious effects of schizophrenia on network performance appear to be localized as reduced regional efficiency in hubs such as the frontal associative cortices, the paralimbic/limbic regions and a subcortical structure (the left putamen). Additionally, scores on the Positive and Negative Symptom Scale correlated negatively with efficient network properties in schizophrenia. These findings suggest that complex brain network analysis may potentially be used to detect an imaging biomarker for schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Anatomical Connectivity Diffusion Tensor Imaging Graph Theory Small-world Schizophrenia
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	WHITE-MATTER INTEGRITY ; GRAPH-THEORETICAL ANALYSIS ; COMPLEX BRAIN NETWORKS ; LONGITUDINAL FASCICULUS ; FUNCTIONAL CONNECTIVITY ; ONSET SCHIZOPHRENIA ; DIFFUSION ; TRACTOGRAPHY ; MRI ; ABNORMALITIES
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000298210600028
引用统计	被引频次：137[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3167
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan 3.Natl Yang Ming Univ, Collage Med, Dept Psychiat, Taipei 112, Taiwan 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Natl Yang Ming Univ, Inst Neurosci, Brain Connect Lab, Taipei 112, Taiwan 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Wang, Qifeng,Su, Tung-Ping,Zhou, Yuan,et al. Anatomical insights into disrupted small-world networks in schizophrenia[J]. NEUROIMAGE,2012,59(2):1085-1093.
APA	Wang, Qifeng.,Su, Tung-Ping.,Zhou, Yuan.,Chou, Kun-Hsien.,Chen, I-Yun.,...&Lin, Ching-Po.(2012).Anatomical insights into disrupted small-world networks in schizophrenia.NEUROIMAGE,59(2),1085-1093.
MLA	Wang, Qifeng,et al."Anatomical insights into disrupted small-world networks in schizophrenia".NEUROIMAGE 59.2(2012):1085-1093.